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Immunology 2018
J u l y 0 5 - 0 7 , 2 0 1 8
V i e n n a , A u s t r i a
Page 97
Journal of Clinical Immunology and Allergy
ISSN 2471-304X
1 5
t h
I n t e r n a t i o n a l C o n f e r e n c e o n
Immunology
Background:
In Ethiopia, only a few studies on the seroprevalence of toxoplasmosis have been carried out among HIV/AIDS
patients. The objective of this study was to determine the seroprevalence of toxoplasmosis among HIV/AIDS patients at Tikur
Anbessa Specialized Hospital, Ethiopia and to determine risk factors associated with seroprevalence.
Materials & Methods:
Blood samples were collected from randomly selected 150 HIV-positive patients, IgM and IgG anti-
toxoplasma antibodies were quantified by using Enzyme immunoassay technique (Human-ELISA, Germany). Ethical approval for
the study was obtained from the Institutional Review Board of the Faculty of Medicine, Addis Ababa University. Questionnaire was
administered to assess the risk factors associated with the prevalence of toxoplasmosis in HIV patients.
Results:
Of the 150 patients, 108 (72%) were females and 42 (28%) were males. The mean (sd) age was 38.4 (9.5). Based on IgG
anti-Toxoplasma antibodies status, the seroprevalence of toxoplasmosis in HIV-positive patients was 94%. No IgM antibody was
detected. Consumption of raw vegetables and not having primary information about toxoplasmosis were significant association
with the presence of anti-toxoplasma antibody (p<0.05). Inexact logistic regression analysis of consumption of raw vegetable
(adjusted OR=7.49, 95% CI 1.29-58.93) was significant risk factor for toxoplasmosis and having information about toxoplasmosis
(adjusted OR=0.083, 95% CI, .011-.499) had significant protective effect. The mean (sd) CD4 count was 341.1(173.6) cells/µl.
The association between the presence of anti-toxoplasma antibody and CD4+ T lymphocyte cells count was not statistically
significant.
Conclusions & Recommendations:
The findings showed that there is a high prevalence of chronic toxoplasmosis in HIV/AIDS
patients and the risk factors were consumption of raw vegetable and lack of information about toxoplasmosis. Therefore, routine
screening for Toxoplasma should be undertaken for all HIV-infected patients. Moreover, creating awareness about toxoplasmosis
and its risk factors should be prioritized
leule@rocketmail.comSeroprevalence of immunoglobulinG and of
immunoglobulinM anti-Toxoplasma gondii antibodies
in human immunodeficiency virus infection/acquired
immunodeficiency syndrome patients at Tikur
Anbessa Specialized Hospital, Addis Ababa, Ethiopia
Yizengaw H A
1
, Tilahun G
2
, Fekade D
1
, Berhe N
2
and Medhin G
2
1
Addis Ababa University, Ethiopia
2
Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Ethiopia
Insights Allergy Asthma Bronchitis 2018, Volume: 4
DOI: 10.21767/2471-304X-C1-003