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Case Reports 2018
Medical Case Reports
ISSN: 2471-8041
Page 60
May 28-29, 2018
London, UK
8
th
Edition of International Conference on
Clinical and Medical Case Reports
S
yndrome of inappropriate antidiuretic hormone secretion
(SIADH) has been described in a variety of viral infections.
It has not been previously reported in cases of dengue fever.
Herein, we report a case of SIADH in the setting of acute dengue
fever in a patient returning from an endemic area. A 65 years old
Dominican woman with PMH of hypothyroidism (on replacement
therapy), OMS/Dementia (on memantine), gastroesophageal
reflux disease (GERD) (on esomeprazole - a PPI), hyperlipidemia
(on atorvastatin) and osteopenia (on ibandronate) was admitted
after returning from vacation in the Dominican Republic with fever
and diffuse abdominal pain. She tested positive for dengue fever.
On presentation, she had serum sodium of 135 with normal renal
function. Because of her N/V, shewas given IVhydrationwith 0.9%
normal saline (NS). Her serum sodium fell over the next 24 hours
to 121 (serum osmolality 242) and then by 48 hours to 113. Her
urine osmolality was 609. Adrenal and thyroid function tests were
within normal limits. She had no known cardiac or liver disease.
She was given a presumptive diagnosis of SAIDH and was treated
with 2% saline which raised her serum sodium to 118 over the
next 24 hours and then to 126 by 48 hours. No secondary cause of
SIADHwas found. She was also placed on fluid restriction and her
serumsodium remained stable in the 125-128 range over the next
five days (urine osmolality 614 at that time) and then gradually
rose to 133-134 over the subsequent remaining five days of her
hospitalization.
amv3@cumc.columbia.eduDengue fever and SIADH: a case report
Anthony M Valeri
Columbia University Medical Center, USA
Med Case Rep. 2018, Volume 4
DOI: 10.21767/2471-8084-C1-003