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Cardiology Insights 2019
Journal of Heart and Cardiovascular Research
ISSN: 2576-1455
Page 43
March 07-08, 2019
Berlin, Germany
New Horizons in Cardiology
& Cardiologists Education
22
nd
International Conference on
J Heart Cardiovasc Res 2019, Volume 3
DOI: 10.21767/2576-1455-C1-003
New method for determining blood pressure in
unanaesthesized rats using noninvasive CONTEC 08A
device with small cuff: A path to antihypertensive drug
development in developing countries
Abiola Muhammad Adeosun, Ighodaro O M
and
Akinloye O A
Lead City University, Nigeria
Federal University of Agriculture, Nigeria
I
nvasive method of determining blood pressure has
been the commonly used method in animal model
of hypertension study. Currently used noninvasive
blood pressure monitoring devices are very costly and
unaffordable by researchers from developing or under
developed countries. In our study, we designed a new
method for determining blood pressure in animal model
studies by using CONTEC 08A device with small cuff
for rats. Ten male Wistar rats of 182-240 g body weight
were randomly assigned to two groups (n=5/group). A
group served as control (without treatment), the second
group was administered dexamethasone (2mg/kg of
body weight) supplemented with 4% table salt (NaCl) as
drinking water to induce hypertension. Blood pressure
was measured ten times in each rats of the two groups
at baseline (day 0) and after 5 days. Reproducibility (Sw)
was calculated in each group. CONTEC 08A yielded good
reproducibility in both hypertensive (SBP, Sw=6 mm Hg,
DBP, Sw=10 mm Hg) and non-hypertensive rats (SBP,
Sw=3 mm Hg, DBP, Sw=6 mm Hg). Better reproducibility
was obtained in non-hypertensive rats. Consistency in
data obtained showed that noninvasive blood pressure
monitoring using CONTEC 08A device with small cuff is
effective, and recommendable for use in rat model study
of hypertension.
adeosun.amuhammad@lcu.edu.ng