Cardiology Insights 2019
Journal of Heart and Cardiovascular Research
ISSN: 2576-1455
Page 46
March 07-08, 2019
Berlin, Germany
New Horizons in Cardiology
& Cardiologists Education
22
nd
International Conference on
J Heart Cardiovasc Res 2019, Volume 3
DOI: 10.21767/2576-1455-C1-003
The stress hyperglycemia in the acute phase of a STEMI: a
residual risk in the era of primary angioplasty?
Mekhdoul, Talamali, Messai
and
Bouame
Service of Cardiology, HCA
H
yperglycemia observed at the admission of a STEMI
is associated with a poor prognosis. This association
has been reported before and after the era of coronary
revascularization in particular non-diabetic patients
and would be sharper and more important in the era of
primary angioplasty.
Methodology & Theoretical Orientation
: Compare
the impact of admission hyperglycemia in STEMI on
in-hospital mortality in patients undergoing primary
angioplasty to those with no reperfusion therapy.
Population & Methods
: A prospective, multicenter study
with a recruitment of 1222 consecutive patients without
a prior history of diabetes and HbA1C <6.5% in the first
24 hours of STEMI
Findings
: The average age of the population was 60.28
yrs +/- 13 yrs, the mean glycemia on admission was 1.39
g/L +/- 0.333, 56.2% of the patients benefit from early
coronary reperfusion, the in-hospital mortality was 7.2%.
The results showed a linear correlation between the level
of glycemia on admission and in-hospital mortality, an
increase of 10 mg/L of serum glucose was associated
to an increased mortality of 2.6% (2.0-3.3), p<0.001.
The mortality was higher in the population of patients
who haven’t receive any reperfusion therapy was 12.2%
versus 3.3% (p<0.001). But the impact of the glycemia on
admission seems more important on the population of
reperfused patient adjusted OR à 5.2 (1.5-17.5), p=0.008
versus adjusted OR 2.7 (1.3-5.38), p=0.005.
Conclusion & Significance
: Hyperglycemia on admission
is an independent predictive factor of short termmortality
in non-diabetic patients during the acute phase of STEMI,
its impact is more important in patients who benefit from
a revascularisation therapy at an early stage.