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Cardiology Insights 2019

Journal of Heart and Cardiovascular Research

ISSN: 2576-1455

Page 46

March 07-08, 2019

Berlin, Germany

New Horizons in Cardiology

& Cardiologists Education

22

nd

International Conference on

J Heart Cardiovasc Res 2019, Volume 3

DOI: 10.21767/2576-1455-C1-003

The stress hyperglycemia in the acute phase of a STEMI: a

residual risk in the era of primary angioplasty?

Mekhdoul, Talamali, Messai

and

Bouame

Service of Cardiology, HCA

H

yperglycemia observed at the admission of a STEMI

is associated with a poor prognosis. This association

has been reported before and after the era of coronary

revascularization in particular non-diabetic patients

and would be sharper and more important in the era of

primary angioplasty.

Methodology & Theoretical Orientation

: Compare

the impact of admission hyperglycemia in STEMI on

in-hospital mortality in patients undergoing primary

angioplasty to those with no reperfusion therapy.

Population & Methods

: A prospective, multicenter study

with a recruitment of 1222 consecutive patients without

a prior history of diabetes and HbA1C <6.5% in the first

24 hours of STEMI

Findings

: The average age of the population was 60.28

yrs +/- 13 yrs, the mean glycemia on admission was 1.39

g/L +/- 0.333, 56.2% of the patients benefit from early

coronary reperfusion, the in-hospital mortality was 7.2%.

The results showed a linear correlation between the level

of glycemia on admission and in-hospital mortality, an

increase of 10 mg/L of serum glucose was associated

to an increased mortality of 2.6% (2.0-3.3), p<0.001.

The mortality was higher in the population of patients

who haven’t receive any reperfusion therapy was 12.2%

versus 3.3% (p<0.001). But the impact of the glycemia on

admission seems more important on the population of

reperfused patient adjusted OR à 5.2 (1.5-17.5), p=0.008

versus adjusted OR 2.7 (1.3-5.38), p=0.005.

Conclusion & Significance

: Hyperglycemia on admission

is an independent predictive factor of short termmortality

in non-diabetic patients during the acute phase of STEMI,

its impact is more important in patients who benefit from

a revascularisation therapy at an early stage.