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Cardiology Insights 2019
Journal of Heart and Cardiovascular Research
ISSN: 2576-1455
Page 44
March 07-08, 2019
Berlin, Germany
New Horizons in Cardiology
& Cardiologists Education
22
nd
International Conference on
J Heart Cardiovasc Res 2019, Volume 3
DOI: 10.21767/2576-1455-C1-003
Relationship between the insulin resistance and circulating
predictive biochemical markers in metabolic syndrome
among young adults in western Algeria
Mohammed Ilyes Belhayara A
University of Oran, Algeria
Aim
: The metabolic syndrome (MetS) becomes
increasingly obvious from an early age. The current
study aimed at exploring the relationship between insulin
resistance and the main biomarkers of MetS in young
adult Algerian patients.
Methods
: Glucose, HbA1C, total cholesterol (TC), high
density lipoprotein cholesterol (HDL-C), low density
lipoprotein cholesterol (LDL-C), insulinemia and
C-peptide, adipokines (leptin, adiponectin), inflammatory
cytokines (IL-6 and TNF-a), us-CRP and GLP-1 were
measured by suitable methods. Homeostasis model
assessment (HOMA) was used to detect the degree of
insulin resistance.
Results
: The MetS patients displayed higher glucose,
insulin, HbA1c values and impaired lipid profile as judged
by increasing TC, TG, LDL-C levels and lower HDL-C.
Furthermore, adipokines, HDL-C and CRP contents were
significantly higher whilst TG and LDL-Cweremuch lower
in MetS female group as compared to male patients
suggesting most pronounced metabolic perturbation in
the latter group.Theprobability of a significant correlation
between HOMA and studied variables was often higher in
female than male subjects. Such was the case for total
cholesterol, HDL-cholesterol, triglycerides, adiponectin,
interleukin-6, TNF-a and hs-CRP.
Conclusion
: The high rate of metabolic syndrome among
young obese adults is alarming; this requires extensive
investigations in prone subjects.