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allied
academies
August 14-16, 2017 | Toronto, Canada
BRAIN DISORDERS AND DEMENTIA CARE
4
th
International Conference on
Neurosurg, an open access journal
ISSN: 2471-9633
Background:
The present study was designed to study
anxiolytic property of aqueous extracts of
Mercurialis
annua
; an important and commonly used for its medicinal
properties belongs to Euphorbiaceae family.
Methods:
The anxiolytic activity was evaluated with the
adult mice by hole board test, and the light–dark box test,
and motor coordination with the rota rod test. The efficacy
of the plant extract (100–600 mg/kg) was compared with the
standard anxiolytic drug diazepam (1 mg/kg)
Results:
The extract increased the time spent in the brightly-
lit chamber of the light/dark box, as well as in the number
of times the animal crossed from one compartment to the
other. Performance on the rota rod was unaffected. In the
hole board test, the extract significantly increased head-dip
counts.
Mercurialis annua
, in contrast to diazepam, had no
effect on locomotion.
Conclusions:
These results provides support for anxiolytic
activity of
Mercurialis annua
, in line with its medicinal
traditional use, and may also suggest a better side-effect
profile of Mercurialis anua relative to diazepam.
Keywords:
Anxiety,
Mercurialis annua
aqueous extract, Rota
rod test, Hole board test, Light–dark test, Morocco
Speaker Biography
Zouhra Doukkali works as a faculty member at University Mohammed V of Rabat at
Morocco
e:
d.zouhra@yahoo.frAnxiolytic activity of aerial part of
Mercurialis annua
aqueous extract in using light/dark and hole
board tests
Zouhra Doukkali
University Mohammed V of Rabat, Morocco
Zouhra Doukkali, Neurosurg 2017, 2:2
DOI: 10.21767/2471-9633-C1-006