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August 14-16, 2017 | Toronto, Canada
BRAIN DISORDERS AND DEMENTIA CARE
4
th
International Conference on
Neurosurg, an open access journal
ISSN: 2471-9633
Background:
Alzheimer’s disease (AD) is a progressive
neurodegenerativedisorder that accounts for themajor cause
of dementia in the world. It is pathologically characterized by
deposition of β-amyloid (Aβ) peptides which influenced by
oxidative stress and mitochondrial dysfunction. Vinpocetine
increases cerebral blood flow, glucose uptake and has
memory-enhancing properties. Epigallocatechin-3-gallate
(EGCG) is a natural chelator and has health-promoting
effects in CNS. Coenzyme Q10 (CoQ10) is an intracellular
antioxidant and mitochondrial membrane stabilizer, while
Vitamin E (VE) and Selenium (Se) are antioxidants and have
ability to counteract free radicals.
Objective:
To evaluate and compare the potential protective
effects of Vinpocetine either alone or in combination with
EGCG, CoQ10 or VE & Se against aluminum-induced AD in
rats. Methods: Nine groups of rats were treated daily for
four weeks with either saline for control group, AlCl3 (70
mg/kg I.P) for AD model group or received together with
AlCl3 each of the following treatments: EGCG (10 mg/kg,
I.P), CoQ10 (200mg/kg, P.O), VE (100 mg/kg, P.O) & Se (1
mg/kg, P.O) as well as Vinpocetine (20 mg/kg, P.O) either
alone or in combination with each of them. Changes in
brain Aβ, tau protein, ACHE, monoamins, inflammatory
mediators, oxidative parameters as well as brain derived
neurotrophic factor (BDNF) were measured. In addition, DNA
fragmentation and Histopathological changes in different
brain regions were also detected for all groups.
Results:
Brain neurological damages characterizing AD
rat's model were established. All treated groups showed
different degrees of protection against hazards of AlCl3.
Their protection was indicated by the significant decrease in
Aβ, tau protein, ACHE, MDA, TNF-α, IL-1β together with the
increase in SOD, TAC, monoamins, BDNF and confirmed by
the histopathological examinations as well as the protection
of DNA from fragmentation. Vinpocetine either alone or in
combination with other treatments especially EGCG showed
better results than each individual treatment.
Conclusion:
Vinpocetine showed higher protection against
AD induced by AlCl3 in rats than all other used individual
treatments, but its combined therapy with these treatments
especially with EGCG showed more pronounced protection.
Key words:
Alzheimer’s disease; Vinpocetine; Epigallocatechin-
3-gallate; Coenzyme Q10; Vitamin E & Selenium; Rats
Speaker Biography
Prof. Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology
from Faculty of Pharmacy, Cairo University. Her postdoctoral studies included different
scientific aspects related to her specialization field with giving especial interest to
researches of neuropharmacology and psychopharmacology; she also developed
research line of behavioral pharmacology in Egypt. She is member of many scientific
societies in Egypt as well as of (AAPS) American Association of Pharmaceutical Scientists
(2002) and (ISTAART) The Alzheimer's Association International Society to Advance
Alzheimer's Research and Treatment (2016). She published more than 50 papers in
reputed journals, supervised and discussed more than 80 PhD, MSc thesis and actively
participated by oral and posters presentations at many international conferences
especially on Alzheimer's disease & Dementia as Dementia 2015, 2016 and Alzheimer's
Association International Conference (AAIC 2016). She has many appreciation
certificates and certificate of best presentation award at 19th International Conference
on Environmental Pollution and Pollution Control (ICEPPC 2017). Now she is a Head
of Pharmacology and Toxicology Department at Al-Azhar University and she sacrifices
great effort hoping to find real treatment that can prevent or delay the progression
of Alzheimer's disease especially in the high-risk individuals focusing on depression,
stress and malnutrition
e:
azzamoro@gmail.comComparative Study on the Influence of Vinpocetine Alone or in Combination with different drugs
against Aluminum-induced Alzheimer’s disease in Rats
Azza A. Ali
1
, Mona M. Kamal
1
, Mona G Khalil
2
, Doaa M. Abd El-latif
3
, karema Abu-Elfotuh
1
1
Department of Pharmacology and Toxicology;
3
Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
2
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt
Azza A. Ali et al., Neurosurg 2017, 2:2
DOI: 10.21767/2471-9633-C1-006