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August 14-16, 2017 | Toronto, Canada
BRAIN DISORDERS AND DEMENTIA CARE
4
th
International Conference on
Neurosurg, an open access journal
ISSN: 2471-9633
Background:
Alzheimer's disease (AD) is a neurodegenerative
disease characterized by deposition of Beta-amyloid
peptides (Aβ), accumulation of neurofibrillary tangles and
memory loss. Social isolation (SI) may exacerbate memory
deficits where the risk of cognitive decline may be lower
by maintaining social connections. Protein malnutrition
(PM) increases oxidative damage in cortex, hippocampus,
cerebellum and is implicated in the progression of AD.
Objective:
To study the influence of SI together with PM
for different periods on DNA fragmentation, β-Secretase,
biochemical and histopathological changes in normal rat
brain as well as to investigate their possible interaction
during induction and progression of AD.
Methods:
Rats were daily treated either for three or
four weeks as following: Normal control received saline,
Control AD model injected by ALCl3 (70 mg/kg, IP), SI-
associated AD model, PM (10% casein diet)-associated AD
model, SI-associated PM model and SI&PM-associated
AD model. Isolated rats were housed individually in cages
covered with black plastic. Biochemical changes in the
brain as acetyl cholinesterase (ACHE), Aβ, tau protein,
brain derived neurotrophic factor (BDNF), monoamins
(DA, 5-HT, NE), inflammatory mediators (TNF-α, IL-1β),
oxidative parameters (MDA, SOD, TAC) and β-Secretase as
well as DNA fragmentation were estimated for all groups.
Histopathological changes in different brain regions were
also evaluated.
Results:
SI together with PM for three and four weeks
resulted in brain neurological damage indicated by significant
increase in β-Secretase, Aβ, tau protein, ACHE, MDA, TNF-α,
IL-1β and DNA fragmentation as well as significant decrease
in SOD, TAC, BDNF and monoamins in both normal and AD
brain. However, brain neurological damage was more severe
when SI and PM were associated with AD especially after 4
weeks. These results were confirmed by histopathological
changes in different brain regions.
Conclusion:
SI and/or PM induced brain neuronal
degenerations. More pronounced and sever effects were
shown after 4 weeks especially in AD model. Consequently,
socialization and adequate protein nutrition are advised
especially with AD to avoid the severity and the progression
of the disease.
Key words:
Alzheimer’s disease; Social isolation, Protein
malnutrition, Neuronal degeneration, Socialization, Rats
Speaker Biography
Prof. Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology
from Faculty of Pharmacy, Cairo University. Her postdoctoral studies included different
scientific aspects related to her specialization field with giving especial interest to
researches of neuropharmacology and psychopharmacology; she also developed
research line of behavioral pharmacology in Egypt. She is member of many scientific
societies in Egypt as well as of (AAPS) American Association of Pharmaceutical Scientists
(2002) and (ISTAART) The Alzheimer's Association International Society to Advance
Alzheimer's Research and Treatment (2016). She published more than 50 papers in
reputed journals, supervised and discussed more than 80 PhD, MSc thesis and actively
participated by oral and posters presentations at many international conferences
especially on Alzheimer's disease & Dementia as Dementia 2015, 2016 and Alzheimer's
Association International Conference (AAIC 2016). She has many appreciation
certificates and certificate of best presentation award at 19th International Conference
on Environmental Pollution and Pollution Control (ICEPPC 2017). Now she is a Head
of Pharmacology and Toxicology Department at Al-Azhar University and she sacrifices
great effort hoping to find real treatment that can prevent or delay the progression
of Alzheimer's disease especially in the high-risk individuals focusing on depression,
stress and malnutrition.
e:
azzamoro@gmail.comThe Possible Interaction between Social Isolation and Protein Malnutrition on Induction and
Progression of Alzheimer’s disease in Rats
Azza A. Ali
1
, Mona M. Kamal
1
, Asmaa Saleh
2
, Hanan A. Abd El-Samea
3
, karema Abu-Elfotuh
1
1
Pharmacology & Toxicology Department
2
Biochemistry Department
3
MSc of Pharmacology & Toxicology, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
Azza A. Ali et al., Neurosurg 2017, 2:2
DOI: 10.21767/2471-9633-C1-006