3 / 17
Page 53
Notes:
allied
academies
August 14-16, 2017 | Toronto, Canada
BRAIN DISORDERS AND DEMENTIA CARE
4
th
International Conference on
Neurosurg, an open access journal
ISSN: 2471-9633
Background:
Alzheimer’s disease (AD) is a progressive
neurodegenerative disorder, oxidative stress plays pivotal
role in damaging membrane integrity and reducing nerve
cells. Cocoa beans can protect the body from the impact of
free radicals and promote better memory. Epigallocatechin-
3-gallate (EGCG) can reduce iron-accumulation in instance
of neurodegenerative diseases while Vinpocetine (Vinp)
increases cerebral blood flow. Coenzyme Q10 (CoQ10) also
causes improvement of cognitive functions. Wheat grass
possesses essential vitamins, minerals and trace elements,
vitamins play important roles against brain damage especially
when used together or with selenium (Se).
Objective:
To evaluate the potential protective effects of
Cocoa alone or together with either EGCG, Vinp, CoQ10,
Wheat grass, Vitamin B complex or combination of Vitamin
E, C and Selenium (Se) against aluminum-induced AD in rats.
Methods: Nine groups of rats were used and injected daily
for four weeks; either with saline for control or with AlCl3
(70mg/kg I.P) for AD model groups. One of AD groups served
as model control while the others received together with
AlCl3 either Cocoa (24mg/kg, P.O) alone or in combination
with EGCG (10mg/kg, I.P), Vinpocetine (20mg/kg, P.O),
CoQ10 (200mg/kg, P.O), Wheat grass (100 mg/kg, P.O),
Vitamin B complex (0.2 mg/kg, P.O) as well as combination of
VE (100mg/kg, P.O), VC (400mg/kg P.O) and Se (1mg/kg, P.O).
Behavioral performance in Y-maze and conditional avoidance
test as well as changes in brain Aβ, tau, β-secretase, brain
derived neurotrophic factor (BDNF), ACHE, monoamins,
inflammatory mediators (TNF-α, IL-1β), oxidative parameters
(SOD, TAC, MDA) were measured for all groups. In addition,
DNA fragmentation and histopathological changes in
different brain regions were also detected.
Results:
Brain neurological damage characterizing AD model
were detected. All treated groups showed protection against
hazards of AlCl3 but combined therapy showed better
results than Cocoa alone especially with Vinp or EGCG as
indicated by the significant decrease in Aβ, β-secretase, tau,
ACHE, MDA, TNF-α, IL-1β together with increase in SOD, TAC,
brain monoamins, BDNF and confirmed by histopathological
examinations as well as the decrease in DNA fragmentation.
Conclusion:
Combination of Cocoa with Vinp or EGCG
showed higher protection against AD induced by AlCl3 in
rats than either cocoa alone or together with all other used
treatments.
Key words:
Alzheimer’s disease; Cocoa; Vinpocetine;
Epigallocatechin-3-gallate; Coenzyme Q10; Wheat grass;
Vitamin B complex; Vitamin E, C & Selenium; Rats.
Speaker Biography
Prof. Azza A Ali has completed her PhD specialized in Pharmacology and Toxicology
from Faculty of Pharmacy, Cairo University. Her postdoctoral studies included different
scientific aspects related to her specialization field with giving especial interest to
researches of neuropharmacology and psychopharmacology; she also developed
research line of behavioral pharmacology in Egypt. She is member of many scientific
societies in Egypt as well as of (AAPS) American Association of Pharmaceutical
Scientists (2002) and (ISTAART) The Alzheimer's Association International Society to
Advance Alzheimer's Research and Treatment (2016). She published more than 40
papers in reputed journals, supervised and discussed more than 60 PhD and MSc
thesis and actively participated by oral and posters presentations at many international
conferences especially on Alzheimer's disease & Dementia as Dementia 2015, 2016
and Alzheimer's Association International Conference (AAIC 2016). Now she is a Head
of Pharmacology and Toxicology Department at Al-Azhar University and she sacrifices
great effort hoping to find real treatment that can prevent or delay the progression
of Alzheimer's disease especially in the high-risk individuals focusing on depression,
stress and malnutrition.
e:
azzamoro@gmail.comEvaluate the impact of Cocoa either alone or in combination with other Neutriceuticals against
Alzheimer’s disease induced by aluminum in rats
Azza A. Ali
1
, Rehab Refat
2
, Mona G. Khalil
3
, Mona M. Kamal
1
, Manal M. Abd-Elhady
4
, Karema Abu-Elfotuh
1
1
Department of Pharmacology and Toxicology;
2
Department of Biochemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
3
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Modern University for Technology and Information, Cairo, Egypt.
4
Ain Shams University hospital
Azza A. Ali et al., Neurosurg 2017, 2:2
DOI: 10.21767/2471-9633-C1-006