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Page 48
alliedacademies
August 17-18, 2017 | Toronto, Canada
ANNUAL BIOTECHNOLOGY CONGRESS
Ann Biol Sci, 2017
ISSN: 2348-1927
Mating MH positive pigs to MH positive pigs produces
an F1 generation that is highly stress susceptible.
Recording the MUP shows MH + pigs have a higher U voltage
than control pigs. Older MH+ pigs have an even higher U
voltage than control pigs. The duration of the voltage spike
is also increased in MH+ pigs versus control pigs and older
MH+ pigs have even a longer duration of the voltage spike.
We can assume that by concentrating the MH genetic defect
in the F1 generation that the population of defective sodium
channels in the acetylcholine receptor was present at a high
concentration. Since the acetylcholine receptors are spatially
located under the foot piece of the myoneural junction
which makes them a bank of receptors that are readily
accessible when acetylcholine is released by the nerve,
and the action of acetylcholine is very rapid. Therefore, the
electromyographic data reflects the genetically defective
sodium channels as the major functional component when
we recorded the data. The sodium channels can be likened
to a low voltage switch in a telephone circuit that is used
to route telephone calls. We would suggest that the sodium
channel at the acetyl choline receptor has been adapted
to produce heat as well as muscle contraction and that the
ability to produce copious amounts of heat is the biological
mechanism that differentiates warm blooded animals from
cold blooded animals.
e:
Malignant hyperthermia: the motor unit potential (MUP) predicts susceptibility to developing the MH
syndrome
Charles H Williams
The Williams Research Laboratory, USA
Ann Biol Sci, 2017, 5:3
DOI: 10.21767/2348-1927-C1-003