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Volume 3, Issue 2
Insights in Analytical Electrochemistry
ISSN: 2470-9867
Analytical Chemistry-Formulation 2017
August 28-30, 2017
Page 42
8
th
Annual Congress on
&
14
th
International Conference and Exhibition on
August 28-30, 2017 Brussels, Belgium
Analytical and Bioanalytical Techniques
Pharmaceutical Formulations
Synthetic steps towards reversible chalcogen-based sensing of essential neurodegenerative disease
factors
David G Churchill
1,2
, Sandip V Mulay
1,2
, Youngsam Kim
1,2
and
Tesla Yudhistira
1,3
1
Korea Advanced Institute of Science and Technology, South Korea
2
Institute for Basic Science, Republic of Korea
3
Indonesia Endownment Fund for Education, Indonesia
T
he chemical etiology of neurodegenerative diseases, is multifactorial and relates to proteins, biomolecules, as well as small
soluble analytes including metal ions and ROS. The over-abundance of ROS/RNS could be an indication of Alzheimer’s
and/or Parkinson’s disease (PD). Recent articles by us and other researchers have begun connecting the dots of this small
molecule chemistry. There is an incredible interest in preparing next-generation (e.g. ROS) probes that are reversible, sensitive,
and also robust. Hypotheses involve also discrepancies inmetal ion concentrations in various regions the brain; some metals are
redox active. Concentrations and the innate chemistry of selenium for example may connect to proposed/tentative etiology of
dementia. For all of these reasons and more, we feel that the pursuit of studying, e.g. organoselenium chemistry in this context
will be fruitful for years to come. In this oral presentation and discussion, selenium, a key element in the redox chemistry of
life and for its ability to engage in catalysis, is presented and debated in terms of diagnosis (probing), as well as potentially in
therapy. To-date, the role of fluorescence and fluorescent molecules in diagnosis, treatment, as well as in biomedical research,
has great current medicinal significance; this is the focus of concentrated effort across the scientific research spectrum. In
particular, organoselenium and/or organosulfur molecules show great promise in the detection of reactive oxygen/nitrogen
species (ROS/RNS) - key factors in ageing/neurodegenerative disease in living systems. The boron dipyrromethene (BODIPY)
system is a versatile class of fluorescent dye; it is commonly used in labelling, chemosensing, light-harvesting, and solar cell
applications due to the many compelling characteristics, including an intense absorption profile, a sharp fluorescence emission
spectrum, and high fluorescence quantum yield. As part of our ongoing effort to study chalcogenide systems, dithiomaleimide-
and phenylselenide probes (among many others) have been designed, synthesized and characterized. Commonly, fluorescence
is quenched by photoinduced electron transfer (PeT) mechanism. These probes show a “turn-on” fluorescence response upon
reaction with ONOO- (BDP-NGM) and HOCl (Mes-BOD-SePh) with significant increase in emission intensity with fast
response to ROS/RNS. Related studies with superoxide have also been published. Live cell imaging showed that the current
probes can be used for the selective detection of ROS and RNS in living systems.
Biography
David G. Churchill obtained a BS degree in Chemistry at the University at Buffalo(NY) while performing X-ray crystallographic studies. He then studied under
professor Gerard (Ged) Parkin at Columbia University (NY). After his PhD, he served as a postdoctoral fellow for professor Kenneth N. Raymond in the Department
of Chemistry at UC Berkeley (CA). He started his academic career in South Korea since 2004 and then became full professor at Korea Advanced Institute of
Science and Technology (KAIST) in 2017.
dchurchill@kaist.ac.krDavid G Churchill et al., Insights in Analytical Electrochemistry, 3:2
DOI: 10.21767/2470-9867-C1-002