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Volume 3, Issue 2
Insights in Analytical Electrochemistry
ISSN: 2470-9867
Analytical Chemistry-Formulation 2017
August 28-30, 2017
Page 30
8
th
Annual Congress on
&
14
th
International Conference and Exhibition on
August 28-30, 2017 Brussels, Belgium
Analytical and Bioanalytical Techniques
Pharmaceutical Formulations
Applications of near infrared and Raman spectroscopy for the analysis of counterfeit medicines
K Dégardin
and
Y Roggo
Roche, Switzerland
C
ounterfeiting is a crime with dreadful consequences, especially in the case of medicines. All type of counterfeits can be
found, from the ones devoid of Active Pharmaceutical Ingredient (API) to under dosed medicines. Fast and reliable
analyses are consequently necessary to confirm the cases and evaluate the risk encountered by the patients. Near Infrared
Spectroscopy (NIRS) and Raman spectroscopy present many advantages for that purpose. There are indeed both fast, non-
destructive methods, that provide chemical information about the analysed samples. The advances in technology enabled
their miniaturisation and therefore their use on the field for even faster analyses. Thanks to chemo-metric tools, the chemical
signature of a suspect sample can be rapidly compared to the genuine references, providing a fast yes/no answer. Three
applications will be presented for the analysis of counterfeit medicines. The first methods that will be presented consist of the
NIR identification with a lab instrument, using different chemo-metric models, of all the tablets produced by Roche, which
represents 30 pharmaceutical products. The described method will also be applied to the detection of counterfeits of these
products. The performance of two NIR handheld spectrometers will then be presented for the analysis of counterfeited tablets
on the field. The complementarity of NIR with Raman spectroscopy will finally be illustrated through examples of spectral
analysis of both solid and biological products.
Biography
Klara Dégardin is working at Roche Pharmaceuticals in Switzerland, and is responsible for the Anti-Counterfeiting lab. She is holder of a master’s degree in
Chemistry and of a PhD in forensic science. She has been working at Roche since 2007, and within the complaints and counterfeits group has specialized in various
analytical methods like Raman and near infrared spectroscopy.
klara.degardin@roche.comK Dégardin et al., Insights in Analytical Electrochemistry, 3:2
DOI: 10.21767/2470-9867-C1-002