advanced-materials-nano-engineering-2018-tracks

Page 24

Volume 4

December 10-12, 2018

Rome, Italy

Nano Research & Applications

ISSN: 2471-9838

Advanced Materials 2018

Nano Engineering 2018

JOINT EVENT

International Conference on

Advanced Materials

and Simulation

Edition of International Conference on

Nano Engineering &

Technology

his presentation will focus on the mechanistic rationale

for using lasers in medicine, biology and principles of

tumor engineering to address chemoresistance in cancer.

Physiological barriers to drug delivery and therapy induced

molecular selection pressures preclude durable improvements

in survival for many cancer patients. It is increasingly evident

that the most effective treatments will involve cooperative

regimens that target multiple non-overlapping pathways, while

minimizing systemic toxicities. Photodynamic therapy (PDT) is

a light based treatment that can improve the therapeutic index

of traditional and emerging treatments. The photochemical

cytotoxic mechanisms triggered by PDT induce damage to

sub cellular organelles, prime tumor cells, disrupt stromal

compartments and enhance drug delivery. This presentation

will describe key factors that guide the development of PDT

based therapeutic regimens. A specific focus is on enhancing

the efficacy of camptothecin analogues and platinum based

chemotherapies, which are commonly used tomanage cancers,

but suffer from significant toxicities, poor drug penetration and

resistance. PDT overcomes these barriers of efficacy, due to its

distinct mechanisms and non-overlapping toxicities. Capturing

these attributes in rationally designed combinations leads to

synergistic tumor reduction in 3D models and durable tumor

control in orthotopic xenograft mouse models for ovarian and

pancreatic cancer. The mechanistic basis of these improved

outcomes will be presented by harnessing photo initiated sub

cellular cytotoxic mechanisms (e.g. damage to mitochondria/

ER and degradation of bcl-2) to prime tumor cells for

subsequent mechanistically distinct chemotherapeutic

insult, thereby lowering the threshold to tumor destruction;

stromal and vasculature disruption to improve drug delivery,

significantly enhancing the penetration of chemotherapeutics

and increasing intratumoral accumulation by >10 fold and

mitigation of chemotherapy induced enrichment of cellular

stemness markers (e.g. CD44, CXCR4) to provide significant

and sustained reductions in local and distant tumor burden and

prolonged improvements in survival. Results will be discussed

in the context of imaging and therapeutic applications of

light, bioengineered 3D models and targeted drug delivery for

inhibition of molecular survival pathways in tumors.

Biography

Imran Rizvi has completed his PhD in Engineering Sciences in the Thayer

School of Engineering at Dartmouth College, an MS in Tumor Biology in

the Lombardi Comprehensive Cancer Center at Georgetown University,

and a BA at Johns Hopkins University. He was an Assistant Professor of

Dermatology (tenure-track) at Harvard Medical School (HMS) and an Assis-

tant Biomedical Engineer at the Wellman Center for Photomedicine (WCP),

Massachusetts General Hospital (MGH), Boston. His expertise is in imaging

and therapeutic applications of light, bioengineered 3D models and animal

models for cancer and targeted drug delivery for inhibition of molecular sur-

vival pathways in tumors. His K99/R00 (NCI) develops photodynamic ther-

apy (PDT) based combinations against molecular pathways that are altered

by fluidic stress in ovarian cancer. He is also Co-PI on an Innovation Award

with Bristol-Myers Squibb to develop optical techniques in immuno oncol-

ogy for light-based modulation of immune response. He has co-authored

39 peer-reviewed publications and five book chapters with a focus on PDT,

biomedical optics and molecular targeting in cancer. He is a Council Mem-

ber of the of the American Society for Photobiology (ASP), Chair of the ASP

Awards Committee and Secretary of the Executive Committee of the Pan

American Photodynamic Association. He serves in several organizing com-

mittees and Scientific Advisory Boards including the Program Committee

for SPIE Photonics West (BIOS Conference B0110) and the World Congress

of the International Photodynamic Association.

imran.rizvi@unc.edu

Fluidic stress modulates biomarker expression and

therapy response in 3D ovarian cancer nodules

Imran Rizvi

University of North Carolina, USA

Imran Rizvi, Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C7-027