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Page 20
Volume 4
December 10-12, 2018
Rome, Italy
Nano Research & Applications
ISSN: 2471-9838
Advanced Materials 2018
Nano Engineering 2018
JOINT EVENT
22
nd
International Conference on
Advanced Materials
and Simulation
&
22
nd
Edition of International Conference on
Nano Engineering &
Technology
A
great effort is being expended during the last years in order
to find new strategies able to increase the efficacy and to
reduce the deleterious side effects of the drugs currently used
for the therapy of cancer. It has been widely demonstrated
that the antineoplastic therapies with either conventional or
single-targeted drugs could take advantage from a combined
treatment with omega-3 polyunsaturated fatty acids (omega-3
PUFA). These nutrients, normally present in our diet, especially
in marine fish, have been demonstrated to be safe at the
concentrations generally used in human trials, and to be
able to modulate molecules involved in cancer cell growth,
differentiation and survival. It is accepted that inflammation
plays a key role in the development of cancer and, among
the mechanisms most often invoked to explain the anti-
neoplastic role of omega-3 PUFA, there is their ability to act
as potent anti-inflammatory agents. In particular, colorectal
cancer (CRC) has been extensively studied among the most
common malignancies in the Western world. In the present
study, solid lipid nanoparticles (SLN), characterized by a lipid
matrix containing resveratrol esterified to stearic acid, have
been synthesized and used to encapsulate docosahexaenoic
acid (DHA) and α-linolenic acid (LNA). Our aim was to increase
the ef ciency of the incorporation of these fatty acids into the
cells and to prevent their peroxidation and degradation. The
resveratrol-based SLN were characterized for their physical-
chemical properties, including their antioxidant and for their
anti-neoplastic activity. It was observed that the encapsulation
of omega-3 PUFA into the SLN enhanced signi cantly their
incorporation in human HT-29 CRC cells in vitro, and their
growth inhibitory effects in these cancer cells, mainly by
reducing cell proliferation.
Recent Publications
1. Serini S and Calviello G (2018) Long-chain omega-3
fatty acids and cancer: any cause for concern? Current
Opinion in Clinical Nutrition & Metabolic Care 21:83-
89.
2. Serini S, Cassano R, Corsetto P A, Rizzo A M,
Calviello G and Trombino S (2018) Omega-3 PUFA
loaded in resveratrol-based solid lipid nanoparticles:
physicochemical properties and antineoplastic
activities in human colorectal cancer cells in vitro.
International Journal of Molecular Sciences 19: pii:
E586.
3. Serini S, Ottes Vasconcelos R, Fasano E and Calviello
G (2016) How plausible is the use of dietary n-3 PUFA
in the adjuvant therapy of cancer? Nutrition Research
Reviews 29:102-125.
4. Serini S, Ottes Vasconcelos R, Fasano E, Calviello
G (2016) Epigenetic regulation of gene expression
and M2 macrophage polarization as new potential
omega-3 polyunsaturated fatty acid targets in
colon inflammation and cancer. Expert Opinion on
Therapeutic Targets 20:843-858.
5. Serini S, Zinzi A, Ottes Vasconcelos R, Fasano E, Riillo
MG, Celleno L, Trombino S, Cassano R, Calviello G
(2016) Role of β-catenin signaling in the anti-invasive
effect of the omega-3 fatty acid DHA in human
melanoma cells. Journal of Dermatological Science
84:149-159.
Physicochemical properties and antineoplastic
effect of omega-3 PUFA loaded in resveratrol-based
solid lipid nanoparticles in human colorectal cancer
cells
in vitro
S Serini
1
, R Cassano
2
, P A Corsetto
3
, A M Rizzo
3
, G Calviello
1
and
S Trombino
2
1
Universita Cattolica del Sacro Cuore Italy
2
Università della Calabria, Italy
3
Università degli Studi di Milano, Italy
S Serini et al., Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C7-027