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Vascular Surgery 2019 Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482 Page 70
March 28-29, 2019
Rome, Italy
Vascular Surgery
4th Edition of World Congress & Exhibition on
J Vasc Endovasc Therapy 2019, Volume 4
DOI: 10.21767/2573-4482-C1-006
Chronic venous insufficiency: a new concept to understand
pathophysiology at the microvascular level - a pilot study
Omar Mutlak, Mohammed Aslam and Nigel J. Standfield
Imperial College London, UK
Objectives: The real mechanism for the development
of the later stages of chronic venous insufficiency still
remainsunclear. Venoushypervolemiaandmicrovascular
ischemia have been reported to be the consequences
of venous insufficiency. The aim of this study was to
investigate the effects of induced venous hypovolemia by
dorsiflexion exercise in patients with venous leg ulcers.
Methods: Thirty-six participants, all of whomhad an ankle
brachial pressure index between 0.8 and 1.2mmHg, were
chosen for this study. The participants were divided
into two groups: Group A, a non-exercise group and
Group B which performed regular exercise in the form of
dorsiflexion. The basic assessment, including the history
and examination, ankle-brachial pressure index (ABPI),
Duplex scan and tcPO2 measurements, was performed
on two occasions at the beginning of the trial and after
three months.
Results: The tcPO2 level was low in the beginning in all
the subjects, but the picture was different at the end of
the trial. There was a significant increase in the tcPO2
level (p<0.001) in the patients who performed exercise
while there was no difference in the measurements
(p>0.05) in the non-exercise group.
Conclusions: Induced venous hypovolemia through
regular evacuation of the peripheral venous system
improved tissue oxygenation at skin level. Venous
hypervolemia may be the main contributing factor for
the development of venous hypoxia and microvascular
ischemia.