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Page 74
May 24-25, 2018
London, UK
Vascular Surgery 2018
3
rd
Edition of World Congress & Exhibition on
Vascular Surgery
Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482
Aim:
The risk factors for peripheral artery disease (PAD) are more
commoninIndigenousthannon-IndigenousAustralians.However,
the presentation and outcome of PAD in Indigenous Australians
has not been previously investigated. The aim of this prospective
cohort study was to compare the presenting characteristics and
clinical outcome of Indigenous and non-Indigenous Australians
with PAD.
Methods:
PAD patients were prospectively recruited since
2003 from an outpatient vascular clinic in Townsville, Australia.
Presenting symptoms and risk factors in Indigenous and non-
Indigenous patients were compared using Pearson’s χ2 test
and Mann Whitney U test. Kaplan Meier survival analysis and
Cox proportional hazard analysis compared the incidence of
myocardial infarction (MI), stroke or death (major cardiovascular
events) among Indigenous and non-Indigenous patients.
Results:
401 PAD patients were recruited, of which 16 were
Indigenous and 385 were non-Indigenous Australians. Indigenous
Australians were younger at entry (median age 63.3 [54.7-
67.8] vs. 69.6 [63.3-75.4]), more commonly current smokers
(56.3% vs. 31.4%), and more frequently had insulin treated
diabetes (18.8% vs. 5.2%). During a median follow-up of 2.5
years, five and 45 combined events (MI, stroke or death) were
recorded amongst Indigenous and non-Indigenous Australians,
respectively. Indigenous Australians were at a 4-fold greater risk
of major cardiovascular events (adjusted hazard ratio 4.03 [95%
confidence intervals 1.17-13.87], p=0.027) compared to non-
Indigenous Australians.
Conclusions:
These findings suggest that Indigenous Australians
with PAD present at a younger age have higher rates of smoking
and insulin-treated diabetes, and poorer clinical outcomes
compared to non-Indigenous Australians
Recent Publications
1. Singh T P, Morris D R, Smith S, Moxon J V and Golledge
J (2017) Systematic review and meta-analysis of the
association between C-reactive protein and major
cardiovascular events in patients with peripheral artery
disease. European Journal of Vascular and Endovascular
Surgery 54(2):220-33.
2. Morris D, Singh T, Moxon J, Smith A, Stewart F, Jones
R, et al. (2017) Assessment and validation of a novel
angiographic scoring system for peripheral artery
disease. British Journal of Surgery 104(5):544-54.
3. Singh T P, Vangaveti V N, Kennedy R L and Malabu
U H (2016) Role of telehealth in diabetic foot ulcer
management – A systematic review. Australian Journal
of Rural Health 24(4):224.
4. Nair J J and Singh TP (2017) Sjogren’s syndrome: review
of the aetiology, pathophysiology & potential therapeutic
interventions. Journal of Clinical and Experimental
Dentistry 9(4):e584-e9.
5. Singh T P, Vangaveti V N and Malabu U H (2015)
Dipeptidyl peptidase-4 inhibitors and their potential
role in the management of atherosclerosis—a review.
Diabetes & Metabolic Syndrome: Clinical Research &
Reviews 9(4):223-9.
Comparison of presenting characteristics and cardiovascular
outcome between Indigenous and non-Indigenous patients with
peripheral artery disease
Tejas P Singh
1, 2, 3
, Joseph V Moxon
1
, Genevieve N Healy
3
, Yvonne Cadet James
4
and
Jonathan Golledge
1, 2
1
Queensland Research Centre for Peripheral Vascular Disease - JCU, Australia
2
Townsville Hospital, Australia
3
The University of Queensland, Australia
4
James Cook University, Australia
Tejas P Singh et al., J Vasc Endovasc Therapy 2018, Volume 3
DOI: 10.21767/2573-4482-C1-002