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May 24-25, 2018
London, UK
Vascular Surgery 2018
3
rd
Edition of World Congress & Exhibition on
Vascular Surgery
Journal of Vascular and Endovascular Therapy
ISSN: 2573-4482
Introduction:
This study was undertaken to verify if simvastatin
modulates Cav-1/eNOS expression and if this modulation is
associated with changes in pro- and anti-inflammatory cytokines
and Toll-like receptor 4 (TLR4) in abdominal aortic aneurysm
(AAA).
Methods:
This was undertaken on non-statin (n=12) and
simvastatin-treated patients (n=24) who underwent open AAA
repair. Patients were treated with simvastatin at a dose of 20 or
40 mg/day for at least 6 months. The tissue samples of AAA wall
were analyzed for Cav-1, eNOS, interleukin 6 (IL-6), IL-10, IL-17
and TLR4 at the gene and protein level.
Results:
Simvastatin treatment significantly and dose-
dependently decreased Cav-1 and increased eNOS expression in
AAA wall (p<0.05 and p<0.01, respectively). The changes in Cav-1
and eNOS were associated with increased concentration of IL-10
(p=0.055) but not IL-6, IL-17 or TLR4 expression in AAA wall.
Conclusions:
Simvastatin may modulate Cav-1 and eNOS
expression in aneurysmal wall indicating a new beneficial role of
statins in AAA patients
Recent Publications
1. Piechota Polanczyk A, Demyanets S, Nykonenko O, Huk
I, Mittlboeck M, Domenig C M, Neumayer C, Wojta J,
Nanobachvili J and Klinger M (2013) Decreased tissue
levels of cyclophilin A, a cyclosporine a target and
phospho-ERK1/2 in simvastatin patients with abdominal
aortic aneurysm. Eur J Vasc Endovasc Surg 45:682-688.
2. Huk I, Nanobashvili J, Neumayer C, Punz A, Mueller M,
Afkhampour K, Mittlboeck M, Losert U, Polterauer P, Roth
E, Patton S and Malinski T (1997) L-arginine treatment
alters the kinetics of nitric oxide and superoxide release
and reduces ischemia/reperfusion injury in skeletal
muscle. Circulation 96:667-675.
3. Ricchiuti V, Lapointe N, Pojoga L, Yao T, Tran L, Williams
G H and Adler G K (2011) Dietary sodium intake regulates
angiotensin II type 1, mineralocorticoid receptor, and
associated signaling proteins in heart. J Endocrinol
211:47-54.
4. Testa A, Spoto B, Sanguedolce M C, Parlongo R M, Pisano
A, Tripepi G, Benedetto F A, Mallamaci F and Zoccali
C (2012) eNOS and caveolin-1 gene polymorphisms
interaction and intimamedia thickness: a proof of concept
study in ESRD patients. Am J Hypertens 25:103-08.
5. Johnston W F, Salmon M, Su G, Lu G, Stone M L, Zhao
Y, Owens G K, Upchurch G R Jr. and Ailawadi G (2013)
Genetic and pharmacologic disruption of interleukin-
1beta signaling inhibits experimental aortic aneurysm
formation. Arterioscler Thromb Vasc Biol 33(2):294-304.
Biography
Aleksandra Piechota Polanczyk is currently employed as an Associate Professor at the
Department of Medical Biotechnology, at the Jagiellonian University in the frame of the
project entitled: Role of heme oxygenase 1 in the development and progression of abdom-
inal aortic aneurysm. She received her PhD in Medicine with specialty of Medical Biology
in 2011. She was a leading Researcher in Prof. Ihor Huk research group (VASLAB) at the
Medical University of Vienna (Austria) with whom she is now cooperating. She is an author
and a co-author of 37 publications published in Polish and foreign international journals (28
original papers and 8 review articles). Her research interests focuses on finding of new an-
ti-oxidative and anti-inflammatory proteins that could be potential markers and/or targets
in treatment of gastrointestinal and cardiovascular diseases, as well as the role of Nrf2 and
heme oxygenase 1 in cellular adaptation to oxidative stress and inflammatory reactions
piechota.aleksandra@gmail.comDifferent
caveolin-1
and
eNOS
expression in simvastatin-treated
patients with abdominal aortic aneurysm
Aleksandra Piechota Polanczyk
1, 3
, Karolina Kowalska
1, 2
, Dominika Ewa Habrowska
Górczyńska
2
, Christoph Neumayer
1
, Michael Bolliger
1
, Christoph Domenig
1
, Markus
Klinger
1
, Josif Nanobaschvili
1
, Agnieszka Wanda Piastowska Ciesielska
2
and
Ihor Huk
1
1
Medical University of Vienna, Austria
2
Medical University of Lodz, Poland
3
Jagiellonian University, Poland
Aleksandra Piechota Polanczyk et al., J Vasc Endovasc Therapy 2018, Volume 3
DOI: 10.21767/2573-4482-C1-002