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Preventive Medicine 2018
Journal of Preventive Medicine
ISSN: 2572-5483
Page 58
July 16-17, 2018
London, UK
9
th
Edition of International Conference on
Preventive Medicine
& Public Health
A
ccumulating evidences support that the expression and
function of long non-coding RNAs (lncRNAs) associated
with blood cancers development and progression. Here, we
evaluate the aberrant expression of lncRNAs in the prediction
of leukemia risk by a meta-analysis of the 16 published studies
involving 697 healthy controls and 781 individuals with leukemia.
The combined analysis showed that lncRNAs was associated
with the increased risk of leukemia (OR= 89.83, 95% CI: 29.50-
273.55，P<0.00001). Quantitative analysis of single lncRNA
showed that low expression of lncRNAs-H19 (OR= 112.9, 95%
CI : 24.08–529.39), the overexpression of DLEU1(OR= 74.41,
95% CI: 1.08-5104.09), DLEU2 (OR=76.14, 95% CI:1.53–3782.4),
LUNAR1(OR=291.65,95% CI:15.66–5433.21), P15AS (OR=87.25,
95% CI:7.72–986.52) and HULC (OR=201.97, 95% CI: 24.96–
1634.33) were associated with the increased risk of leukemia.
Moreover, the abnormal expression of LUNAR1, p15AS, HULC
were related to acute leukemia, while DLEU2 and H19 abnormally
expressed were related to chronic leukemia patients. In addition,
MLL-r acute leukemia related to 7 lncRNAs (OR= 14.97, 95% CI:
5.37-41.75). These results identified strong associations between
lncRNAs abnormal expression and leukemia. Some lncRNAs may
be novel diagnostic markers for leukemia.
jiangnia_6900@qq.comAssociations of long non-coding RNAs and leukemia: A meta-
analysis
Caixia Wang
1
, Huanyu Shen
1, 2
, Chanjiao Zheng
2
and
Shunqing Wang
1
1
Guangzhou First People’s Hospital, China
2
Guangzhou Medical University, China
J Prev Med 2018, Volume 3
DOI: 10.21767/2572-5483-C1-003