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E u r o s c i c o n C o n f e r e n c e o n
Physical Chemistry and
Analytical Separation Techniques
October 08-09 , 2018
Amsterdam, Nether l ands
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Physical Chemistry and Analytical Separation Techniques 2018
I
n the last decades, several epidemiological studies have confirmed the increase in the frequency of invasive fungal infections
(IFIs) worldwide, which are currently considered important public health problem. Clinical and experimental evidence has shown
that IFIs can be caused by organized communities in the form of biofilms. These structures are characterized by intense metabolic
cooperation and great resistance to physical and chemical agents and are defined as dynamic communities of microorganisms
strongly adhered to a biotic/abiotic substrate and protected by a matrix rich in exopolymers, especially proteins. The extracellular
matrix of the biofilm plays a crucial role in the protection of fungal cells against the immune response of the host besides being
considered one of the main mechanisms of resistance to antifungals. Understanding the mechanisms involved in the synthesis
of the biofilm matrix is the key point for the development of antifungal strategies. There are several techniques for identifying the
components of the biofilmmatrix, one of them is the matrix assisted laser desorption/ionization time-of-flight mass spectrometry
(MALDI-TOF MS), which allows analyzing the biofilmmatrix constituents. Thus, this communication aims to emphasize the use of
the MALDI-TOF MS technique as a tool for the development of antifungal strategies.
tony_biomed@hotmail.comThe use of the matrix-assisted laser desorption/
ionization time-of-flight mass spectrometry
(MALDI-TOF MS) technique for the development of
antifungal strategies
Antonio Jose de Jesus Evangelista
Federal University of Ceará, Brazil
J Org Inorg Chem 2018 Volume: 4
DOI: 10.21767/2472-1123-C6-018