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E u r o s c i c o n C o n f e r e n c e o n
Physical Chemistry and
Analytical Separation Techniques
October 08-09 , 2018
Amsterdam, Nether l ands
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Physical Chemistry and Analytical Separation Techniques 2018
G
arcinia atroviridis
locally known as
asamgelugor
inMalaysia can be foundwild in the forest of peninsular Malaysia. Traditionally,
G. atroviridis
has been used as a postpartummedication agent to treat earache, throat irritation, cough, dandruff and stomach
ache. The essential oils from different plant parts of
G. atroviridis
, viz., fruit, stem bark and leaf were obtained by hydrodistillation.
Analysis by gas chromatography and gas chromatography-mass spectrometry revealed the presence of sesquiterpenoids in
the fruit and leaf oils while fatty acids was predominated in the stem bark oil.
In vitro
MTT assay on human breast cancer cells
showed that the leaf oil induced anti-proliferative effects in a dose- and time-dependent manner. In a combination treatment with
tamoxifen, the leaf oil induced more cell death than the treatment using the drug alone. Thus, there is a need to further explore
G.
atroviridis
essential oils as this may lead to the discovery of potential chemotherapeutic agents.
tanwn@usm.myWen Nee Tan, Melati Khairuddean and Nik Nur Syazni Nik
Mohamed Kamal
1
Universiti Sains Malaysia (USM), Malaysia
J Org Inorg Chem 2018 Volume: 4
DOI: 10.21767/2472-1123-C6-018
The potential of Garcinia atroviridis as
therapeutic agents