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Pharmacognosy 2019
March 11-12, 2019
London, UK
Pharmacognosy and
Medicinal Plants
7
th
Edition of International Conference on
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 20
Protection from hepatic ischemia and improvement
of liver regeneration by
Thuja orientalis
Alok Kumar Dash
V B S P University, India
L
iverisavitalorganperformingwiderangeoffunctions;
oxidative damage is implicated in the pathogenesis
of various liver disorders. Present study was aimed at
evaluating protective ability of
Thuja orientalis
Linn.
against thioacetamide induced hepatotoxicity in rats.
Thuja orientalis
has been used in ayurvedicmedicine for
the treatment of various disorders.
Thuja orientalis
has
the biological capabilities of detoxication, antioxidation
and antiinfection. In this study, we evaluated the
antihepatotoxic effect of
Thuja orientalis
aqueous
and petroleum ether extract on the thioacetamide
induced liver injury in a rat model. Hepatic damage,
as reveled by histology and the increased activities
of serum aspartate aminotransferase (AST), alanine
aminotransferase (ALT), alkaline phosphatase (ALP)
activities and decreased levels of serum total protein
(TP), albumin (Alb) and globulin (G) were induced in
rats by an administration of 50 mg/kg thioacetamide
was injected intraperitoneally (i.p).
Thuja orientalis
extract significantly inhibited the elevated AST, ALP and
ALT activities and the decreased TP, Alb and G levels
caused by thioacetamide intoxication. From this study,
it can be concluded that the aqueous and petroleum
ether extracts of
Thuja orientalis
possesses effective
hepatoprotective activity.
Biography
Alok Kumar Dash received his B. Pharm from IGIPS, M. Pharma from
KMIPS and PhD Degree from Suresh Gyan Vihar University, Jaipur,
Rajasthan, India. He is working as an Assistant Professor in Institute
of Pharmacy, Veer Bahadur Singh Purvanchal University, U.P, India.
His field of research focuses is on natural products chemistry, phar-
macognosy, pharmacological screening and standardization method
development for herbals. He has more than 40 national and interna-
tional publications and two patents to his credit. He is having 10 years
of experience in research and teaching. His biography is published
in Asian Admirable Achievers (volume ninth) 2016. He is recipient
of most coveted institutional and globally reputed Rashtriya Gaurav
Award 2017. His profile is selected for Bharat Vikas Award. He is re-
cipient of “Certificate of Excellence in Reviewing-2017” by European
Journal of Medicinal Plant, Science Domain International and has
been serving as an Editorial BoardMember of International Journal of
Modern Botany, Scientific and Academic Publishing, Asian Journal of
Chemical Sciences, BMC Complementary and Alternative Medicine,
Boequivalence and Bioavailability International Journal, British Jour-
nal of Pharmaceutical research and many more.
Alok Kumar Dash, Am J Ethnomed 2019, Volume 6
DOI: 10.21767/2348-9502-C1-008