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Pharmacognosy 2019
March 11-12, 2019
London, UK
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 35
Pharmacognosy and
Medicinal Plants
7
th
Edition of International Conference on
Antidiabetic activity and modulation of antioxidant status
by
Ocimum canum
in Streptozotocin-induced diabetic rats
Alok Kumar Dash
VBSP University, India
T
he aqueous extract of
Ocimum canum
(Family:
Lamiaceae) leaf was investigated for its antidiabetic
effect in Wistar Albino rats. Diabetes was induced in
albino rats by administration of streptozotocin (45 mg/
kg, I.P). The aqueous extract of
Ocimum canum
at a
dose of 100 mg/kg and 200 mg/kg of body weight
was administered to diabetes induced rats for a period
of 28 days. The effect of aqueous extract of
Ocimum
canum
leaf extract on blood glucose, plasma insulin,
glycosylated haemoglobin, serum lipid profile low density
lipoprotein (LDL), very low density lipoprotein (VLDL),
high density lipoprotein (HDL), atherogenic index and the
activities of alanine aminotransferase (ALT), aspartate
aminotransferase (AST) and alkaline phosphatase
(ALP) of all groups were analyzed. Antioxidant enzyme
catalases (CAT), superoxide dismutase (SOD), reduced
glutathione (GSH), serum thiobarbituric (TBAR) were
measured in the diabetic rats. The aqueous extract of
Ocimum canum
leaf elicited significant reductions of
blood glucose (p<0.01), lipid parameters except HDL-C,
serum enzymes and significantly increased HDL-C
and antioxidant enzymes. From the above results it
is concluded that aqueous extract of
Ocimum canum
possesses significant antidiabetic, antihyperlipidaemic
and antioxidant effects in streptozotocin induced diabetic
rats.
Biography
Alok Kumar Dash received his B. Pharm from IGIPS, M. Pharma from
KMIPS and PhD Degree from Suresh Gyan Vihar University, Jaipur, Ra-
jasthan, India. He is working as an Assistant Professor in Institute of
Pharmacy, Veer Bahadur Singh Purvanchal University, U.P, India. His
field of research focuses is on natural products chemistry, pharma-
cognosy, pharmacological screening and standardization method de-
velopment for herbals. He has more than 40 national and international
publications and two patents to his credit. He is having 10 years of ex-
perience in research and teaching. His biography is published in Asian
Admirable Achievers (volume ninth) 2016. He is recipient of most covet-
ed institutional and globally reputed Rashtriya Gaurav Award 2017. His
profile is selected for Bharat Vikas Award. He is recipient of “Certificate
of Excellence in Reviewing-2017” by European Journal of Medicinal
Plant, Science Domain International and has been serving as an Editori-
al Board Member of International Journal of Modern Botany, Scientific
and Academic Publishing, Asian Journal of Chemical Sciences, BMC
Complementary and Alternative Medicine, Boequivalence and Bioavail-
ability International Journal, British Journal of Pharmaceutical research
and many more.
Alok Kumar Dash, Am J Ethnomed 2019, Volume 6
DOI: 10.21767/2348-9502-C1-008