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Pharmacognosy 2019
March 11-12, 2019
London, UK
American Journal of Ethnomedicine
ISSN: 2348-9502
Page 33
Pharmacognosy and
Medicinal Plants
7
th
Edition of International Conference on
Anti-aggregant effect of
Rubia tinctorum
extracts on
platelets
in vitro
and
ex vivo
Fatima Zahra Marhoume
1, 2
, Abdellah Bagri
1
, Hicham Boufous
1, 2
, Mehdi Ait
Laaradia
2
and
Abderrahman Chait
2
1
Université Hassan-Ier, Morocco
2
University Cadi Ayyad, Morocco
P
latelets play pivotal role in primary hemostasis and
several cardiovascular diseases (CVD) in athero-
thrombotic disease and are associated with an increase in
blood platelets aggregation.
Rubia tinctorum
(RT) extracts
was investigated for anti-aggregant activity induced by
collagen
in vitro
and
ex vivo
by measuring the bleeding
time and platelets count. Our finding demonstrated that RT
extract showed a significant (P<0.001) inhibition of collagen
induced platelets aggregation (1.48±0.76, n=3). This results
correlate well with data of bleeding time and platelet count.
Phytochemical analysis revealed the presence of flavonoids
which may be implicated in this action.
Biography
Fatima Zahra Marhoume currently working as a professor in Labora-
tory of Pharmacology, Neurobiology and Behavior, Semlalia Faculty of
Sciences, Cadi Ayyad University, Marrakech, Morocco.
Fatima Zahra Marhoume et al., Am J Ethnomed 2019, Volume 6
DOI: 10.21767/2348-9502-C1-008