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Pain Management 2019 & Internal Medicine 2019
International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X
Page 71
JOINT EVENT
7
th
Edition of International Conference on
Pain Management
8
th
Edition of International Conference on
Internal Medicine &
Patient Care
&
March 25-26, 2019
Rome, Italy
Int J Anesth Pain Med 2019, Volume 5
DOI: 10.21767/2471-982X-C1-006
Relation of anthropometric measures and insulin resistance
with anti-mullerian hormone in premenopausal women
Eman H El-Adawy, Maha M Elshafei Mohamed Sherif Abd Elgawad
and
Soma
sheriff Abd EL Gawad
Mansoura University, Egypt
Introduction:
It has been suggested that obesity is
associated with decreased level of anti-mullerian
hormone (AMH) which considered as a good marker of
ovarian reserve.
Aim:
The aim is to evaluate the association between
obesity and AMH and whether there is relation of the
anthropometric measures and insulin resistance with the
level of AMH in Egyptian premenopausal women.
Subjects & Methods:
Eighty premenopausal women
with BMI more than 30 (obese group) and 80 age-
matched healthy lean women (control group). BMI, waist
circumference (WC), bloodpressure (BP) weremeasured.
Fasting blood glucose (FBS), fasting insulin (FI), insulin
resistance (HOMA-IR), high sensitive C-reactive protein
(hs-CRP) and AMH were analyzed.
Results:
AMH levels in obese group were significantly
lower than control group. There were significant negative
correlations between each of BMI, WC, FBG, hs-CRP, FI
and HOMA-IR with AMH (r =-0.214, -0.226, 0.141, -0.264,
-0.241 and -0.258 respectively) (all p values ≤ 0.05). With
forward stepwise linear regression analysiswe found that
HOMA-IR was significantly and independently related to
AMH; (B=-0.172; 95% CI -0.273: -0.071). Furthermore,
HOMA-IR was confirmed to be an independent predictor
of AMH after adjustment of age and BMI; (B = - 0.173;
95% CI – 0.274; - 0.072) and also by adjustment of age
and WC; (B= -0.135 95%CI -0.268; -0.001).
Conclusion:
Obesity and insulin resistanceareassociated
with decreased ovarian reserve among Egyptian
premenopausal women.
emaneladawy@yahoo.com