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Pain Management 2019 & Internal Medicine 2019 International Journal of Anesthesiology & Pain Medicine
ISSN: 2471-982X Page 70
JOINT EVENT
7th Edition of International Conference on
Pain Management
8th Edition of International Conference on
Internal Medicine &
Patient Care
&
March 25-26, 2019
Rome, Italy
Int J Anesth Pain Med 2019, Volume 5
DOI: 10.21767/2471-982X-C1-006
Direct evidence of viral infection and mitochondrial
alterations in the brain of fetuses at high risk for
schizophrenia
Segundo Mesa Castillo
Havana Psychiatric Hospital, Cuba
Background: There are increasing evidences that favor
the prenatal beginning of schizophrenia.These evidences
point toward intrauterine environmental factors that
act specifically during the second pregnancy trimester
producing a direct damage to the brain of the fetus. The
current available technology doesn’t allow observing
what is happening at cellular level since the human brain
is not exposed to a direct analysis in that stage of the life
in subjects at high risk of developing schizophrenia.
Methods: In1977, we began adirect electronmicroscopic
research of the brain of fetuses at high risk from
schizophrenic mothers in order to finding differences at
cellular level in relation to controls.
Results: In these studies we have observed within
the nuclei of neurons the presence of complete and
incomplete viral particles that reacted in positive form
with antibodies to herpes simplex hominis type I [HSV1]
virus, and mitochondria alterations.
Conclusion: The importance of these findings can have
practical applications in the prevention of the illness,
keeping in mind its direct relation to the aetiology and
physiopathologyofschizophrenia.Astudyofthegametes
or the amniotic fluid cells in women at risk of having a
schizophrenic offspring is considered. Of being observed
the same alterations that those observed previously in
the cells of the brain of the studied foetuses, it would
intend to these women in risk of having a schizophrenia
descendant, previous information of the results, the
voluntary medical interruption of the pregnancy or an
early anti HSV1 viral treatment as preventive measure of
the later development of the illness.