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Organic Chemistry 2018
Journal of Organic & Inorganic Chemistry
ISSN: 2472-1123
Page 36
August 16-17, 2018
Dublin, Ireland
6
th
Edition of International
Conference and Exhibition on
Organic Chemistry
T
he use of automated flow systems combined with on-line MS
analysis enables rapid screening and efficient optimization for
process development and is fully scalable from laboratory, pilot
plant tomanufacturing plant. This produces amassive saving in the
time and materials required if compared to common approaches.
To demonstrate this, we have investigated the optimization of the
nucleophilic aromatic substitution of 2,4-difluoro-nitrobenzene
with morpholine over a wide variety of stochiometric ratios,
residence times and temperatures to demonstrate all the benefits
of using on-line flow reaction monitoring.
Biography
Christopher Harris received his PhD in Chemistry from Nottingham University,
UK studying the mass spectrometry and electrostatics of molecular cluster.
He is an Application Specialist at Microsaic Systems PLC, developers of point-
of-need mass spectrometers that serve a range of applications. His key appli-
cation areas include reaction monitoring and mass directed purification. He is
mainly interested in mass spectrometry.
charris@microsaic.comMultivariate analysis of a nucleophilic aromatic substitution
by real-time on-line flow reaction monitoring using
miniaturized mass spectrometry
Christopher Harris
Microsaic Systems PLC, UK
Christopher Harris, J Org Inorg Chem 2018, Volume 4
DOI: 10.21767/2472-1123-C4-012