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7
t h
E u r o p e a n C o n g r e s s o n
Obesity and
Eating Disorder
Obesity 2018
Journal of Obesity & Eating Disorders
ISSN 2471-8203
A p r i l 1 2 - 1 3 , 2 0 1 8
Am s t e r d a m , N e t h e r l a n d s
Page 53
T
his “Commentary” examines an important clinical
observation that right-sided colorectal cancers appear
less treatable than the left-sided cancers. The concepts of
(a) the “initiation/promotion/progression” process, (b) the
stem cell hypothesis, (c) the role gap junctional intercellular
communication, (d) cancer cells lacking GJIC either because
of the non-expression of connexin genes or of non-functional
gap junction pro-teins, and (e) the role of the microbiome in
promoting initiated colon stem cells to divide symmetrically
or asymmetrically are examined to find an explanation. It
has been speculated that “embryonic-like” lesions in the
ascending colon are initiated stem cells, promoted via
symmetrical cell division, while the polyp-type lesions in
the descending colon are initiated stem cells stimu-lated to
divide asymmetrically. To test this hypothesis, experiments
could be designed to examine if right-sided lesions might
express Oct
4A
and
ABCG2
genes but not any connexin genes,
whereas the left-sided lesions might express a connexin
gene, but not Oct4A or the
ABCG2
genes. Treatment of the
right sided lesions might include transcriptional regulators,
whereas the left-sided lesions would need to restore the
posttranslational status of the connexin proteins.
james_Trosko@hotmail.comWhat roles do colon stem cells and gap junctions
play in the left and right location of origin of
colorectal cancers?
James E Trosko and Heinz-Josef Lenz
Kermanshah University of Medical Sciences, Iran
J Obes Eat Disord 2018, Volume: 4
DOI: 10.21767/2471-8203-C1-009