obesity-2018-posters-accepted-abstracts

t h

E u r o p e a n C o n g r e s s o n

Obesity and

Eating Disorder

Obesity 2018

Journal of Obesity & Eating Disorders

ISSN 2471-8203

A p r i l 1 2 - 1 3 , 2 0 1 8

Am s t e r d a m , N e t h e r l a n d s

Page 53

his “Commentary” examines an important clinical

observation that right-sided colorectal cancers appear

less treatable than the left-sided cancers. The concepts of

(a) the “initiation/promotion/progression” process, (b) the

stem cell hypothesis, (c) the role gap junctional intercellular

communication, (d) cancer cells lacking GJIC either because

of the non-expression of connexin genes or of non-functional

gap junction pro-teins, and (e) the role of the microbiome in

promoting initiated colon stem cells to divide symmetrically

or asymmetrically are examined to find an explanation. It

has been speculated that “embryonic-like” lesions in the

ascending colon are initiated stem cells, promoted via

symmetrical cell division, while the polyp-type lesions in

the descending colon are initiated stem cells stimu-lated to

divide asymmetrically. To test this hypothesis, experiments

could be designed to examine if right-sided lesions might

express Oct

and

ABCG2

genes but not any connexin genes,

whereas the left-sided lesions might express a connexin

gene, but not Oct4A or the

ABCG2

genes. Treatment of the

right sided lesions might include transcriptional regulators,

whereas the left-sided lesions would need to restore the

posttranslational status of the connexin proteins.

What roles do colon stem cells and gap junctions

play in the left and right location of origin of

colorectal cancers?

James E Trosko and Heinz-Josef Lenz

Kermanshah University of Medical Sciences, Iran

J Obes Eat Disord 2018, Volume: 4

DOI: 10.21767/2471-8203-C1-009