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Page 49
Volume 05
Journal of Clinical Nutrition & Dietetics
ISSN: 2472-1921
JOINT EVENT
June 17-18, 2019 London, UK
Nutrition World 2019
Euro Obesity 2019
June 17-18, 2019
&
26
th
World Nutrition Congress
15
th
Euro Obesity and Endocrinology Congress
Advanced glycation end products
Raquel Lima
Institute Kurz, Germany
Statement:
Advanced glycation end-products (AGEs) are a complex group of molecules that have been found almost
everywhere among tissues and organs of the human body and they come not only from an endogenous formation,
but also from exogenous dietary exposure. Their concentration increases with age and a persistent exposure to
elevated levels of endogenous and exogenous AGEs are thought to contribute to the pathogenesis and progression
of a variety of chronic conditions, including type 1 diabetes, type 2 diabetes, neurodegenerative conditions, allergy,
nonalcoholic steatohepatitis, asthma, inflammatory bowel disease, renal disease, and certain cancers. The human
body has evolved a number of detoxification systems to reduce the burden associated with AGEs and their dicarbonyl
precursors. Besides, limiting the dietary intake of foods that have undergone browning by the application of intense
heat, particularly food and beverages containing high levels of protein or carbohydrate derived from simple sugars,
would significantly reduce AGEs consumption. By considering the diverse pathways leading to AGEs formation,
there are also molecular strategies for the inhibition of their formation like the following: antioxidants, metal ion
chelators and compounds able to quench reactive carbonyl species (RCS) which act as AGEs. Another strategy to
lessen the accumulation and to provide protection against the
in vivo
formation of AGEs is to use nutraceuticals that
contain active ingredients derived from foods (e.g., vitamins, amino acids, antioxidants). Combination therapies that
simultaneously target multiple pathways may be more successful than those that modify a single pathway.
r.lima@institut_kurz.de raquel@nutralima.comJ Clin Nutr Diet 2019, Volume 05