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Page 47
Volume 05
Journal of Clinical Nutrition & Dietetics
ISSN: 2472-1921
JOINT EVENT
June 17-18, 2019 London, UK
Nutrition World 2019
Euro Obesity 2019
June 17-18, 2019
&
26
th
World Nutrition Congress
15
th
Euro Obesity and Endocrinology Congress
Effects of probiotics and synbiotic on lipid profiles in adults at risk of type 2 diabetes: A double-blind
randomized controlled clinical trial
Nazila Kassaian
1
, Awat Feizi
1
, Ashraf Aminorroaya
1
, Maryam Tajabadi Ebrahimi
2
, Atsa Norouzi
1
and
Masoud Amini
1
1
Isfahan University of Medical Sciences, Iran
2
Islamic Azad University, Iran
Background:
The use of probiotics and/or prebiotics as the effective means of regulating gut microbiota may have a
beneficial effect on metabolic disorders.
Aims:
This study was designed to assess the ability of probiotics and symbiotic to modify lipid profiles in subjects
with prediabetes who are at risk of diabetes and cardiovascular diseases.
Methods:
In a randomized double-blind placebo-controlled clinical trial, 120 pre-diabetic adults aged 35-70 years
from the first degree family of type 2 diabetic patients were recruited and randomly equally assigned to consume 6 g/d
either probiotics, or symbiotic or placebo supplements for 6 months. Food record, physical activity, anthropometric
measures and lipid profiles were assessed repeatedly at baseline, and 3 and 6 month supplementation.
Results:
Probiotics and symbiotic were effective in reduction of serum triglycerides after 6 months of intervention
(SMD=-10.6 and -9.4 respectively). Compared with the placebo, symbiotic resulted in a significant reduction in
serum triglyceride levels (mean±SD: -9.4±6.6 mg/dl vs. +13.2±6.8 mg/dl, p=0.02). Serum total-, LDL-, and HDL-
cholesterol were unaffected by probiotic or symbiotic.
Conclusion:
The results of this study demonstrated that supplementation with probiotic and especially symbiotic
could decrease the concentration of triglyceride in pre-diabetic adults. This finding could warrant future studies
to determine the therapeutic and preventive effects of these supplements in individuals at risk of diabetes and
cardiovascular diseases.
nkassaian@gmail.comJ Clin Nutr Diet 2019, Volume 05