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Nanobiotechnology 2018
Page 54
Nano Research & Applications
ISSN: 2471-9838
E u r o S c i C o n C o n f e r e n c e o n
Nanotech & Nanobiotechnology
J u l y 1 2 - 1 3 , 2 0 1 8
P a r i s , F r a n c e
A
dvances in the fabrication of nanoparticles with exquisite control over shape, surface chemistry and three-dimensional
architecture have not been matched by a detailed understanding of their biological fate. Recent efforts in our lab have focused
on investigating the influence of particle size, core chemistry, porosity, shape, density, and surface functionality of silica and
dendritic nanoparticles on interactions with macrophages, epithelial barriers and blood cells. A series of nonporous, mesoporous,
spherical and rod or worm shaped silica nanoparticles were synthesized and characterized. Their cellular uptake, cytotoxicity,
biodistribution, and hemocompatibility were investigated and compared to polymeric dendrimers with variations in size and
surface functional groups. In the size regimes studied, results demonstrate that variations in geometry can influence mode of
cellular uptake, surface functionality is a predominant factor in biological fate, cationic poly (amido amine) dendrimers result in
disseminated intravascular coagulopathy, and particle density and porosity influence the rate of uptake and toxicity.
hamid.ghandehari@utah.eduIn vitro
and
in vivo
toxicology of silica and
dendritic nanoparticles
Hamid Ghandehari, Mostafa Yazdimamaghani, Pouya Hadipour,
Raziye Mohammadpour and Zachary B Barber
University of Utah, USA
Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C2-012