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Volume 4
Nano Research & Applications
ISSN: 2471-9838
Page 74
JOINT EVENT
August 16-18, 2018 | Dublin, Ireland
&
12
th
Edition of International Conference on
Nanopharmaceutics and Advanced Drug Delivery
25
th
Nano Congress for
Future Advancements
Nano Congress 2018
&
Nano Drug Delivery 2018
August 16-18, 2018
Apoferritin cage nanostructure as the anthracycline delivery system
Katarzyna Kurzatkowska
1
and
Maria Hepel
2
1
Institute of Animal Reproduction and Food Research - PAS, Poland
2
State University of New York, USA
C
ancer diseases are undoubtedly the most complex diseases known to humanity and one of the greatest problems of the 21st
century. The continuous increase in cancer cases is a serious problem in the sphere of prophylaxis and treatment. According
to the WHO data, in 2012, the number of newly diagnosed cancer cases was as high as 14 million and the estimated number
of new cases per year will increase to 22 million over the next twenty years. During the same period, deaths are projected
to increase from 8.2 million to 13 million per year. The strategy of treating cancer is based on three basic methods: tumor
removal, toxic chemotherapy and radiotherapy. The most developed method is chemotherapy. However, many anticancer
drugs are causing serious side effects. To address the problems with conventional drugs and improve their pharmacological
properties, drug-delivery systems (DDS) have been designed for a number of drug-carrier platforms including synthetic
(silica, polymers) and natural (lipids, proteins, oligosaccharides) nanocarriers. The most recent development in designing
DDS have been focused upon the protein-based nanomedicine platform, due to merits that include high biocompatibility,
biodegradability, high solubility, and ease of surface modification. One of the most investigated classes of protein-nanocages is
ferritin, which in biological system is used to store iron and to keep it from building to toxic levels in cells. Ferritin/Apoferritin
(APO) nanocages have been used to encapsulate a variety of drugs and biologically active substances, including gadolinium
contrast agents, doxorubicin, inorganic and magnetite nanoparticles, photosensitizers, organometallic CO releasing systems
containing Ru and Mn. Here, we present a drug delivery system to protect the anthracyclines cancer drugs in the apoferritin
nanocage. Anthracyclines are the class of drugs used to treat many cancers, including leukemias, lymphomas, breast, stomach,
uterine, ovarian, bladder cancer, and lung cancers. Their main adverse effect is cardiotoxicity, which considerably limits
their usefulness. Here, we demonstrate the differences in the releasing process of anthracyclines (doxorubicin, epirubicin,
daunorubicin and idarubicin) from the APO nanocages. The APO-drug nanocages were prepared by disassembly/reassembly
process via pH method. The pH-dependent anthracyclines release was determined using fluorescence spectroscopy.
k.kurzatkowska@pan.olsztyn.plNano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C3-015