nano-congress-nano-drug-delivery-2018-posters

Volume 4

Nano Research & Applications

ISSN: 2471-9838

Page 71

JOINT EVENT

August 16-18, 2018 | Dublin, Ireland

Edition of International Conference on

Nanopharmaceutics and Advanced Drug Delivery

Nano Congress for

Future Advancements

Nano Congress 2018

Nano Drug Delivery 2018

August 16-18, 2018

Multi-functional magneto-liposomes for photo-thermally triggered drug release and MRI imaging

Wafa T Al Jamal

Queen's University Belfast, UK

agnetic nanoparticles exhibit extraordinary properties, which make an excellent candidate for biomedical applications.

Iron oxide nanoparticles have been used in MRI imaging, drug delivery and cancer hyperthermia. In the present

work we report the engineering of hybrid vesicular systems between temperature-sensitive liposomes (TSL) and magnetic

nanoparticles, as promising smart nanocontainers for photo-thermally triggered drug release and magnetic resonance imaging.

Superparamagnetic iron oxide nanoparticles with different compositions, core sizes, and surface coating were successfully

incorporated into TSL. Liposome-iron oxide hybrids (magneto-liposomes) were prepared using lipid film hydration and

extrusion, and doxorubicin (Dox) was encapsulated in the liposome aqueous core using a remote loading method. The

developed magneto-liposomes were characterized using dynamic light scattering (DLS), transmission electron microscopy

(TEM), inductively coupled plasma mass spectrometry (ICP-MS). Dox release from our novel hybrids was assessed in response

to near infrared radiation (NIR) laser. Magneto-liposomes were also studied to evaluate their capabilities as magnetic resonance

imaging (MRI) contrast agent. Our results revealed that the incorporation of small hydrophobic SPIO in the TSL lipid bilayer

did not affect liposome size, stability and Dox loading. Moreover, our magneto-liposomes showed fast drug release in response

to laser, and superior MRI imaging capabilities compared to free SPIO nanoparticles. In conclusion, we report, for the first

time, novel magneto-liposomes that could be used as a laser-responsive system, and can be combined with MRI for image-

guided drug delivery.

Nano Res Appl 2018, Volume 4

DOI: 10.21767/2471-9838-C3-015