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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
16
th
EuroSciCon Conference on
Immunology
M a r c h 1 1 - 1 2 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Immunology 2019
Objective:
Intestinal amebiasis is still an important health problem in developing
countries of the world. One of the most issues for future biomedical research
is the development of antimicrobial resistant, in order to search for alternative
new antiamoebic drugs. A study was carried out to evaluate the efficacy of
albendazol on the viability of
Entamoeba histolytica
clinical isolate from human
which used for experimental animals.
Material and Methods:
All experimental animal models (30 albino mice and 30
rabbits),divided into 3 groups,each group with either 10 mouse or 10 rabbits,
were orally infected with
E. histolytica
(clinical isolate), then after 7 days
they were given drugs (Metronidazol or Albendazol) daily according to body
weight prepared in advance for 5 days duration and in addition to the controls
without drugs. Stool specimens of each group were examined microspically
for viable trophozoites,and the number of these trophozoites were counted
with haemocytometer chamber, as compared to untreated and treated groups.
Statistical methods used was student t-test.
Results:
The results showed infection of
E.histolytica
was able to be intiated
in rabbits only. Albendazol and metronidazol were highly effective(100%) on
treatment of infected groups of rabbits ( table I ). Trphozoites of
E. histolytica
was highly sensitive to albendazol (25% viability), or to metronidazol (22.7%
viability) at a dose of 400 mg / kg / day and 250 mg / kg / day respectively,which
was significant in relation to the control 500% viability(table II). However, the
differences were significant at the level (p<o.o1).
Conclusions:
The present study showed that the newly used albendazol is very
effective anti-amebic drug as metronidazol in rabbits.
Biography
Abdulsalam Mohamad Kasim Al-Mukhtar has completeted his
Ph.D. at age 37 years, from Salford University (England 1980),
more than 30 research published in different journals,and
he was working as lecturer in dept. of microbiologl,college of
medicine, university of Mosul,Mosul, Iraq for 44 years ago.
salam_1943@yahoo.comEffectienevss of Albendazol against Viability of
Entamoeba
histolytica
in experimental animals
AbdulSalam M. Al-Mukhtar
Dept. of Microbiology,College of Medicine, University of Mosul, IRAQ
AbdulSalam M. Al-Mukhtar, J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-008