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Journal of Clinical Immunology and Allergy
ISSN: 2471-304X
16
th
EuroSciCon Conference on
Immunology
M a r c h 1 1 - 1 2 , 2 0 1 9
Am s t e r d a m , N e t h e r l a n d s
Immunology 2019
Objective:
To assess, in non vaccinated healthy adults, the response to the standard protocol SP of vaccination for hepatitis B (0,
1, 6 months), and the response to two boosters protocols in non-responders (NR).
Methods:
192 adults, mean age of 44.3 receive (Engerix® B 20 µg/1 ml) by the SP. The non-responders (anti-Hbs antibodies
<10UI/l) are divided into two groups. The first group (P1) receives a single booster (R1) 4 months after the SP, and those who
remained non-responders receive a double booster (R1b) 2 years after the SP. The second group (P2) receives a unique double
booster (R2), 2 years after the SP.
Results:
The rate of response after the SP is 75.5 %( 145/192). 28 NR in (P1) have a response rate of 32.14 %( 9/28). The 19 NR
in (R1b) have a response of 36.84 %( 7/19). 19 NR (P2) have a response of 63.16 %( 12/19). 9.9 %( 19/192) of individuals don't
respond to any booster. The rate of response decreases with the age( 5% every year and 41% every 10 years) For the same age,
men are 2 fold more responders then women.
Conclusion:
A unique double booster done 2 years after the SP gives a better response then a single booster done after 4 months,
and a similar response to a single booster done after 4 months followed by a double booster done after 2 years. The female
gender and the age are 2 factors that decrease the response to the vaccination.
jacqueschoucair@hotmail.comVaccination of hepatitis B in healthy adults:
effect of sex and age, two protocols of
revaccination in non-responders
Jacques Choucair
1
and Sleiman Zaki
1
Hotel Dieu de France, Saint-Joseph University Beirut, Lebanon
J Clin Immunol Allergy 2019, Volume:5
DOI: 10.21767/2471-304X-C1-009