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Laser Optics & Photonics and Atomic & Plasma Science 2018
J u l y 1 6 - 1 7 , 2 0 1 8
P r a g u e , C z e c h R e p u b l i c
Page 60
American Journal of Computer Science and Information Technology
ISSN: 2349-3917
E u r o S c i C o n J o i n t E v e n t o n
Laser Optics & Photonics and
Atomic & Plasma Science
Oara Neumann et al., Am J Compt Sci Inform Technol 2018, Volume 6
DOI: 10.21767/2349-3917-C1-002
M
ultifunctional plasmonic nanostructures have enormous potential in the
treatment of solid tumors; however, tracking particles with drug cargo
and triggering the release of the cargo in mapped tumors is still impossible.
To overcome this challenge we have developed an MRI and fluorescent active
nanostructure nanomatryoshka. This new nanostructure with IR plasmonic
signatures is composed of a 50 nm Au core surrounded by dye molecules
and Gd(III)-DOTA chelate doped SiO
2
inner-shell and an outer Au shell. The
experimental results demonstrates an enhanced T
1
relaxation (r
1
~24 mM
-1
s
-1
at 4.7T) compared to the clinical Gd(III)-DOTA chelating agents (r1~4 mM
-1
s
-1
).
Further, this design preserves the fluorescence signal (65%) after 24 hours of
exposure, leading to enahanced fluorescence photostability (23x). This dual-
imaging functionality nanosystem increases MRI sensitivity by concentrating
Gd(III) ions into the Gd-NMs, reduces the potential toxicity of Gd(III) ions and
dye molecules by preventing their release in vivo through the outer Au shell
protection, and the terminal gold layer surface can then be functionalized to
increase cellular uptake, circulation time, or thermal drug-release properties.
Biography
Oara Neumann has completed her PhD and Postdoctoral study
in Applied Physics at Rice University and MS from Weizmann
Institute of Science, Israel and Bucharest University, Romania.
She is a Research Scientist in Naomi Halas group at Rice
University. She holds 12 patents and she has published more
than 25 papers in reputed journals.
Oara.Neumann@rice.eduFluorescent and T1 MRI active multilayer nanoparticle for
imaging and targeting cellular delivery
Oara Neumann
1
, Luke Henderson
1
, Caterina Kaffes
2
, Runmin
Zhang
1
, Valeria S Marangoni
1
, James Bankson
2
, Peter
Nordlander
1
and Naomi J Halas
1
1
Rice University, United States
2
The University of Texas-M D Anderson Cancer Center, United States