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Laser Optics & Photonics and Atomic & Plasma Science 2018
J u l y 1 6 - 1 7 , 2 0 1 8
P r a g u e , C z e c h R e p u b l i c
Page 52
American Journal of Computer Science and Information Technology
ISSN: 2349-3917
E u r o S c i C o n J o i n t E v e n t o n
Laser Optics & Photonics and
Atomic & Plasma Science
Igor Chourpa et al., Am J Compt Sci Inform Technol 2018, Volume 6
DOI: 10.21767/2349-3917-C1-002
Research in nanomedicine is known to be a stimulating field for fruitful interaction between complementary scientific expertises.
Indeed, it integrates the most recent advances in material chemistry, medicinal chemistry, physiology, biotechnology and
biophysics. In the present talk, we will describe how the nanomedicine research can take benefit from the advanced molecular
optical spectroscopy and spectral imaging. Conventional Raman and Surface-Enhanced Raman Scattering (SERS) are analytical
techniques attracting a close attention due to several advantages they offer, namely direct analysis of many complex samples,
with high spatial resolution and high molecular specificity, at relatively low cost. In case of SERS and fluorescence, increased
selectivity and sensitivity are additional advantages. Furthermore, as we demonstrate, it is possible to combine SERS with
fluorescence, either in a frame of a complementary analysis or via the simultaneous co-detection of both scattered and emitted
photons. Such a combination/coupling allows, for instance, a more relevant interpretation of the molecular state and environment
of active ingredients or of nanomedicine platforms in cells and tissues. Nevertheless, spectroscopic analysis of biological
samples leads to collection of complex datasets often subjected to strong variations. It is particularly the case for spectral
imaging, with thousands of spectra recorded when mapping the region of interest. For a more efficient mining of spectroscopic
data, chemometric approaches are necessary. The input of our advanced spectroscopic approaches to nanomedicine research
will be illustrated using their applications to bioanalytics (study of active molecules in pharmaceutic/cosmetic nanoforms and
in biological cells and tissues) as well to diagnostics (development of novel nanoprobes for multimodal biomedical imaging of
cancers). As we show, this input is not limited to characterize/evaluate nanomedicine forms, but it is extended to create novel
spectroscopy-based diagnostic approaches, expected to be more specific, sensitive and reliable.
Recent Publications
1. Gautier J, Allard-Vannier E, Munnier E, Souce M and Chourpa I (2013) Recent advances in theranostic nanocarriers of
doxorubicin based on iron oxide and gold nanoparticles. J Control Release 10;169 (1-2):48-61.
2. Gautier J, Allard-Vannier E, Burlaud-Gaillard J, Domenech J and Chourpa I (2015) Efficacy and Hemotoxicity of Stealth
Doxorubicin-Loaded Magnetic Nanovectors on Breast Cancer Xenografts. J Biomed Nanotechnol 11(1):177-89.
Input Of Raman, SERS And Fluorescence Spectroscopy To
Nanomedicine Research
Igor Chourpa1, Lynda Miloudi1, Franck Bonnier1, Katel Herve-Aubert1,
Mathias Pacaud1,2, Emilie Allard-Vannier1, Emilie Munnier1, Anastasia
Ignatova3, Amir Fahmi2 and Alexey Feofanov3,4
1University of Tours, Tours, France
2Rhein-Waal University of Applied Sciences, Germany
3Shemyakin-Ovchinnikov IBCh RAS, Russia
4Lomonosov Moscow State University, Russia
Biography
Igor Chourpa has completed his PhD from the University of Reims, France in 1996. He joined the University of Tours in 1997. He is the Director of Nanomedicine and Nanoprobes
laboratory (EA6295). This interdisciplinary team develops bio-analytical methods and nanomedicine technology for drug delivery and disease diagnostics. His specialization is in
Molecular Optical Spectroscopy (Raman, SERS, fluorescence and IR) and Spectral Imaging. He has published more than 60 papers in reputed journals and 2 book chapters. He
has experience in coordination of national and international research projects and has been acted as expert for numerous calls. He is an Editorial Board Member of Journal of
Analytical Methods in Chemistry.