8 / 57
Notes:
Volume 3, Issue 2 (Suppl)
Trends in Green chem
ISSN: 2471-9889
Environmental & Green Chemistry 2017
July 24-26, 2017
Page 26
5
th
International Conference on
6
th
International Conference on
July 24-26, 2017 Rome, Italy
Environmental Chemistry and Engineering
Green Chemistry and Technology
&
Flow microreactors enables green chemistry approach for organolithium chemistry
Aiichiro Nagaki
Kyoto University, Japan
P
rotecting-group-free synthesis has received significant recent research interest in the context of ideal synthesis and green sustainable
chemistry. In general, organolithium species react with electrophilic functional groups very rapidly, and therefore such functional
groups should be protected before an organolithium reaction, if they are not involved in the desired transformation. If organolithium
chemistry could be free from such a limitation, its power would be greatly enhanced. A flow microreactor enables such protecting-
group-free organolithium reactions by choosing the appropriate residence time and the reaction temperature. Organolithium species
bearing alkoxycarbonyl, nitro, and ketone carbonyl groups can be generated and reacted with various electrophiles using a flow-
microreactor system. In addition, asymmetric carbolithiation of conjugate enynes can be also achieved without the epimerization of a
configurationally unstable chiral organolithium intermediate based on precise control of the residence time using a flowmicroreactor.
In this presentation, we report that a flow microreactor system enables the generation of various unstable organolithium compounds.
Biography
Aiichiro Nagaki received his PhD in 2005 from Kyoto University under the supervision of Professor Jun-ichi Yoshida. He worked with Professor Hiroaki Suga, Tokyo
University from 2005 as a Postdoctoral Fellow. In 2006, he became an Assistant Professor at Kyoto University. He was promoted to Junior Associate Professor
in 2013. His current research interests are Organic Synthesis, Polymer Synthesis, and Microreactor Synthesis. He has received several awards which includes
Takeda Pharmaceutical Co., Ltd. award in Synthetic Organic Chemistry, Japan (2012), Incentive Award in Synthetic Organic Chemistry, Japan (2012), and Young
Innovator Award on Chemistry and Micro-Nano Systems (2013).
anagaki@sbchem.kyoto-u.ac.jpAiichiro Nagaki, Trends in Green chem, 3:2
DOI: 10.21767/2471-9889-C1-002