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Dental Practice 2019 Dentistry and Craniofacial Research
ISSN: 2576-392X Page 35
January 28-29, 2019
Barcelona, Spain
27th International Conference on
Dentistry and Dental Practice
One type of cancer is oral squamous cell carcinoma, which
is the least studied due to lack of early detection and
has become a serious problem in the field of oral health in
Indonesia as a country which has a high number of active and
passive smokers. The genus Stichopus has a great efficacy
as an anticancer. A combination of amino acids that helps to
synthesize the antioxidant glutathione can definitely reduce
oxidant activity which causes cancer. The purpose of this
research is to determine the effect of golden sea cucumber
(Stichopus hermanni) extracts in apoptosis of oral squamous
cell carcinoma. In this research, there were 25 of Rattus
norvegicus strain wistar that were divided into five treatment
groups i.e., untreated rats, rats with induction of carcinogen
(DMBA solution), rats with treatment dose 0.33 g/kg weight, 0.6
g/kg weight and 0.99 g/kg weight. The result of this research
was the appearance of buccal epithelial cells of the Rattus
norvegicus showed apoptosis from immuno histochemical
staining. There was an increase in apoptosis on treatment with
a dose of 0.99 g/kg weight so that it can be concluded that
the induction of golden sea cucumber (Stichopus hermanni)
extracts to a treatment group affect the oral squamous cell
carcinoma apoptosis.
The implementation of antioxidant (glutathione)
of golden sea cucumber ( Stichopus herrmanni)
extracts in oral squamous cell carcinoma
apoptosis
Nabilah Kusuma Wardhani
Brawijaya University, Indonesia
J Den Craniofac Res 2019, Volume 4
DOI: 10.21767/2576-392X-C1-015