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Dental Practice 2019 Dentistry and Craniofacial Research
ISSN: 2576-392X Page 29
January 28-29, 2019
Barcelona, Spain
27th International Conference on
Dentistry and Dental Practice
Cancer, according to the World Health Organization is
defined as a large group of diseases characterized by the
growth of abnormal cells beyond their usual boundaries that
can then invade adjoining parts of the body and/or spread to
other organs. From extensive surgical excisions, radiotherapy,
laser therapy to immunotherapies, various treatment strategies
have been proposed and implemented so far but unfortunately
none could improve the five year survival rate of the patients
globally. Immunotherapy, being one amongst them, is a type
of cancer treatment that boosts the body’s natural defences
to fight against cancer. The current concept of immunotherapy
involves chimeric antigen receptor or the CAR T-Cell therapy
which involves alterations and modifications of T cells to fight
cancer cells better. Until recently, the use of CAR T-cell therapy
has been restricted to small clinical trials, largely in patients
with advanced blood cancers and has also shown a promising
window of hope in head and neck (especially oral) cancers
as well. But these treatments have nevertheless captured the
attention of the people because of the remarkable responses
they have produced in some patients for whom all other
treatments had stopped working. Aim of the study is to assess
the CAR T-Cell therapy and to find its efficacy in head & neck
malignancies. The research hypothesis is to find the effect of
CAR T-Cell therapy in treating head and neck cancers? Study
sample included review of research articles, based on scientific
data bases from the English literature based COCHRANE
collaboration having a definite RCT (Randomized Control
Trial). The literature was studied, analyzed and assessed;
comparison was made on their p (probability) values between
various techniques in terms of their sensitivity and specificity.
Since the study is still in progress, the result and conclusion
will be discussed on the day of the presentation at the venue.
Biography
Avisesh Manohar is currently pursuing his internship (House Surgeon) at
NSVK Sri Venkateshwara Dental College and Hospital, Bangalore, Karnata-
ka, India. He attended eight CDE programmes and scientific conferences.
He is the winner of best paper at the IAOMR UG Convention 2018.
Efficacy of CAR T-cell therapy in head and neck
cancers: A meta-analysis
Avisesh Manohar
NSVK Sri Venkateshwara Dental College and Hospital, India
Avisesh Manohar, J Den Craniofac Res 2019, Volume 4
DOI: 10.21767/2576-392X-C1-015