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Dentistry and Craniofacial Research
ISSN: 2576-392X
3
rd
Euroscicon Conference on
M a r c h 2 5 - 2 6 , 2 0 1 9
B u d a p e s t , H u n g a r y
Dental Hygiene 2019
Dental & Dental Hygiene
Negar Salehi, Dent Craniofac Res 2019, Volume:4
DOI: 10.21767/2576-392X-C2-018
T
his study investigated the antifungal effect of low molecular weight
chitosan nanoparticle solution and compared it with nystatin suspension.
This randomized single-blind clinical trial study was performed on 40 subjects
diagnosed with denture stomatitis. The subjects were divided into two groups,
one of which was treated with chitosan nanoparticles and one with nystatin
for two weeks. Changes in the erythematous area were recorded during and
after treatment. A palatal smear was obtained for each patient before and
after treatment to determine the number of blastospores and mycelia of
Candida albicans. The results were compared using the Mann-Whitney test
and T-test. The results showed that chitosan nanoparticle solution significantly
decreased the erythematous surface area, burning sensation, time required for
clinical improvement, and number of blastospores and mycelia. The antifungal
efficacy and biocompatibility of chitosan makes it a promising candidate for
use as an antifungal mouthwash.
Biography
Negar Salehi obtained his Doctorate of Dental Surgery (DDS)
from Khourasgan Dental School, Iran. He obtained his PhD
degree from Department of Department of Oral Medicine,
School of Dentistry, Kerman University of Medical Sciences,
Iran, He is working as an Assistant Professor for the same
department, Rafsanjan University of Medical Sciences, Iran.
negarsal66@gmail.comANTIFUNGAL EFFECT OF LOW MOLECULAR WEIGHT CHITOSAN
NANOPARTICLES AGAINST CANDIDA ALBICANS
Negar Salehi
University of Medical Sciences, Iran