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E u r o S c i C o n C o n f e r e n c e o n
Dental & Dental
Hygiene
Dental & Dental Hygiene 2018
Journal of Dental and Craniofacial Research
ISSN 2576-392X
M a r c h 2 6 - 2 7 , 2 0 1 8
E d i n b u r g h , S c o t l a n d
Page 74
Background:
Despite significant improvements in reconstruc-
tion techniques and materials during the last decades, the re-
generation, restoration and/or repair of oro-dental and max-
illo-facial defect remains a challenge. Platelet concentrates
are autologous blood extracts obtained through centrifuga-
tion of whole blood samples. The preparation procedure al-
lows the gathering and concentration of platelets and other
therapeutic blood constituents (fibrinogen/fibrin, growth
factors, leukocytes and circulating cells), in clinically-usable
preparations (surgical adjuvants), which may enhance, ac-
celerate and promote tissue (hard and soft) wound healing
and regeneration. Despite promising clinical observations,
their overall effectiveness remains debated, to date. This
is mainly due to mixed/variable clinical outcomes, limited
high-quality evidence-based literature, and poor character-
ization of end-products (and preparation protocols) used in
studies; also until recently, lack of proper terminology sys-
tems to classify these preparations. Today, the leukocyte and
platelet-rich fibrin (L-PRF) sub-family is receiving the utmost
attention, mainly due to simplicity, user-friendliness, mallea-
bility and potential cost-effectiveness, when compared to the
PRPs.
Objectives & Methodology:
L-PRF is a second generation
3D autogenous/autologous platelet concentrate (and
biomaterial: slowly- and strongly-polymerized fibrin gel; rich
in growth factors and lymphocytes) derived via simple and
rapid centrifugation of whole venous blood, in the absence of
anti-coagulants, bovine thrombin, additives or any gelifying
agents. A relatively new“revolutionary” step inmodernplatelet
concentrate-based therapeutics, clinical effectiveness of
L-PRF remains highly-debatable, whether due to preparation
Leukocyte and platelet-rich fibrin in oro-dental
and maxillo-facial surgery: current evidence
from randomized controlled clinical trials
Ziyad S Haidar
Universidad de los Andes, Chile
protocol variability, limited evidence-based scientific and
clinical literature and/or inadequate understanding of its
bio-components. This critical review provides an update on
the application and clinical potential/effectiveness of L-PRF
during oral surgery procedures, limited to evidence obtained
from human randomized and controlled clinical trials (RCTs:
Jan. 2015–Nov. 2017).
Conclusions:
Autologous L-PRF is often associated with
early bone formation and maturation; accelerated soft-
tissue healing; and reduced post-surgical pain, oedema
and discomfort. Preparation protocols require revision
and standardization. Well-designed RCTs (according to
the CONSORT statement) are also needed for validation.
Furthermore, a better analysis of rheological properties, bio-
components and bioactive function of L-PRF preparations
would enhance the cogency, comprehension and therapeutic
potential of the reported findings or observations, moving
a step closer towards a new era of “super” oro-dental and
maxilla-facial bio-materials/-scaffolds; an ongoing topic of
vital investigation at our BioMAT’X research group in Santiago
de Chile.
zhaidar@uandes.clJ Den Craniofac Res 2018, Volume: 3
DOI: 10.21767/2576-392X-C1-003