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E u r o S c i C o n C o n f e r e n c e o n
Dental & Dental
Hygiene
Dental & Dental Hygiene 2018
Journal of Dental and Craniofacial Research
ISSN 2576-392X
M a r c h 2 6 - 2 7 , 2 0 1 8
E d i n b u r g h , S c o t l a n d
Page 72
T
he aim of this lecture is to present the outcomes of
several experimental therapeutic approaches we tested
in our previous and current research studies such as dentine
specimens air-abraded with bioactive glass 45S5 (BAG)
and then treated with fluoride-releasing glass ionomer
(GIC) or resin-modified glass ionomer cements (RMGIC).
Moreover, experimental resin-based varnishes containing
different bioactive fillers formulated and then applied onto
demineralised dentine pre-treated with or without different
biomimetic primers doped with sodium trimetaphosphate,
aspartic acid (PASA) and/or poly(acrylic acid) (PAA). Dentin
permeability evaluation using a fluid filtration system
working at a simulated pulpal pressure of 20 cm H2O and
finally processed and assessed with AFM nano-indentation,
XRD, FTIR-ATR, FEG-SEM (fractographic analysis), TEM, dye-
Therapeutic operative strategies combined with
bioactive/biomimetic ion-releasing materials on
dentine permeability and remineralisation
Salvatore Sauro
1,2
1
Universidad CEU-Cardenal Herrera, Spain
2
King's College London, UK
assisted confocal microscopy and Raman microscopy. The results
of our studies showed that air-abrasion technique performed with
BAG is able to create a therapeutic “bioactive smear-layer-covered
surface”, which reacted with body fluids, evoking hydroxyapatite
(HAP) precipitation, and hence remineralisation ofmineral-depleted
dentine and occluding the dentinal tubules. These outcomes were
especially evident when BAG air-abraded dentine specimens
treated with GICs or RMGICs. Moreover, the use of experimental
resin-based systems containing bioactive fillers in combination
with biomimetic primers doped with PAA/PASA and TMP evoked
“bottom-up” dentine remineralisation that restored the modulus of
elasticity of demineralised dentine. The application of minimally
invasive therapeutic operative strategies along with the use of
current or innovative ion-releasing containing biomimetic reagents
may represent a suitable strategy to remineralise demineralised
dental hard tissues completely, enhancing the clinical outcomes and
longevity. Moreover, bioactive glasses reacts with saliva depositing
hydroxycarbonate apatite (HCA) within the demineralised collagen
fibrils and occluding dentinal tubules. Therefore, it may be used
as a suitable desensitizing bioactive material for the treatment of
dentine hypersensitivity and as an air-polishing powder to prevent
further demineralisation.
salvatore.sauro@uchceu.esJ Den Craniofac Res 2018, Volume: 3
DOI: 10.21767/2576-392X-C1-003