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Crystallography 2018
Structural Chemistry & Crystallography Communication
ISSN: 2470-9905
Page 65
June 04-05, 2018
London, UK
3
rd
Edition of International Conference on
Advanced Spectroscopy,
Crystallography and Applications
in Modern Chemistry
S
pherical crystallization is usually the last technological step in
the production of solid formdrugs. Not only purification can be
achieved with it, but we can manufacture the optimal morphology
of the crystals. Spherical morphology with suitable mean particle
size is advantageous when direct tablet making technique is
used. This way the amount of the additives can be reduced
and smaller tablets can be produced. In our previous research
[1] it was found that the spherical crystallization of ambroxol
hydrochloride can be achieved by the non-typical methods, such
as spherical agglomeration and cooling crystallization. Because
of the spherical morphology, flowing and compaction properties
of the powder have improved. In the present work the parameter
optimization was further investigated with the help of an FBRM
probe, continuously observing the crystal growth in the non-
typical crystallization systems. With this on line technique, it was
possible to control the mean particle size and the optimal mixing
time, and solvent-antisolvent ratio could also be determined.
In case of the cooling crystallization, we applied an alternating
temperature profile around the metastable zone in order to
standardize the particle size. It was a heating-cooling cycle, so
the smaller particles could dissolve when heating happened, then
crystallize onto the surface of the larger crystals. With the FBRM
probe, this process could be investigated and the exact, optimal
length of the heating-cooling periods could be determined.
gyosaat@gmail.comINVESTIGATING CRYSTAL GROWTH IN AMBROXOL HYDROCHLORIDE
SOLUTIONS WITH THE HELP OF FBRM TECHNIQUE IN CASE OF NON-
TYPICAL SPHERICAL CRYSTALLIZATION METHODS
Orsolya Gyulai
and
Zoltan Aigner
University of Szeged, Institute of Pharmaceutical Technology and Regulatory Affairs, Hungary
Struct Chem Crystallogr Commun 2018, Volume 4
DOI: 10.21767/2470-9905-C1-006