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Volume 3, Issue 2
ISSN: 2470-9905
Crystallography 2017
October 16-17, 2017
2
nd
International Conference on
October 16-17, 2017 | Chicago, USA
Applied Crystallography
Visualization of evaporative crystallization dynamics probed by fluorescence color changes
Fuyuki Ito
Shinshu University, Japan
C
rystal formation from a solution is necessary for the fabrication of organic solid material. In solution crystallization, the formation
of crystal nuclei plays an important role in determining crystal structure, size and polymorphism, and their crystal quality.
Recently, a two-step nucleation model was developed to explain protein crystallization; involving a liquid-like cluster intermediate
before nucleation, which has been shown to be of more general validity. The two-step nucleation model replaces the classical model of
crystallization that is molecules are added on one by one to extend the crystal lattice and form embryo clusters in a one step process.
Liquid-clusters are believed to originate fromdisordered liquids or amorphous metastable clusters in homogeneous solutions. We have
focused the fluorescence detection for crystal formation process. The fluorescence spectra of the materials are sensitive to molecular
environment and aggregation. In principle, the evolution of the molecular assembly can be assessed by fluorescence spectroscopy
on the scale of only a few molecules or a bulk process scale. We have investigated fluorescence spectral changes of perylene and
cyanostilbene derivatives showing aggregation-induced emission during solvent evaporation by fluorescence microscopy. We
have claimed that the information on molecular assembly and crystal nucleation and growth processes is obtained by studying the
concentration-dependent fluorescence spectral change of organic fluorescent dyes in the polymer film and solvent evaporation. In
this paper, we investigate the fluorescence properties of 4,4’-di-
tert
-butyldibenzoylmethane boron difluoride (BF
2
DBMb) solutions
during evaporative crystallization. BF
2
DBMb exhibits mechanofluorochromism, which originates from the different emission
properties of its amorphous and crystalline states.
Biography
Fuyuki Ito received his Ph.D. in 2004 from Tohoku University under the direction of Prof. Shozo Tero-Kubota. He worked as a postdoctoral fellow at Osaka University. He
moved to Kyushu University in 2005 as a research associate. In 2009 he moved to Shinshu University and became an associate professor in 2010. His research interests
photochemistry of molecular-assembly system and crystal formation process of organic molecules.
fito@shinshu-u.ac.jpFuyuki Ito, Struct Chem Crystallogr Commun, 3:2
DOI: 10.21767/2470-9905-C1-002