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academies
August 14-16, 2017 | Toronto, Canada
BRAIN DISORDERS AND DEMENTIA CARE
4
th
International Conference on
Neurosurg, an open access journal
ISSN: 2471-9633
Synthetic steps towards reversible chalcogen-based sensing of essential neurodegenerative disease
David G. Churchill
Korea Advanced Institute of Science and Technology, Korea
T
he chemical etiology of neurodegenerative diseases, is
multifactorial and relates to proteins, biomolecules, as
well as small soluble analytes including metal ions and ROS.
The over-abundance of ROS/RNS could be an indication of
Alzheimer’s and/or Parkinson’s disease (PD).1 Recent articles
by us and other researchers have begun connecting the dots
of this small molecule chemistry. There is an incredible
interest in preparing next-generation (e.g. ROS) probes
that are reversible, sensitive, and also robust. Hypotheses
involve also discrepancies in metal ion concentrations in
various regions the brain; some metals are redox active.
Concentrations and the innate chemistry of selenium for
example may connect to proposed/tentative etiology of
dementia. 2 For all of these reasons and more, we feel that
the pursuit of studying, e.g., organoselenium chemistry in
this context will be fruitful for years to come.3 In this oral
presentation and discussion, selenium, a key element in
the redox chemistry of life and for its ability to engage in
catalysis, is presented and debated in terms of diagnosis
(probing), as well as potentially in therapy. To-date, the role
of fluorescence and fluorescent molecules in diagnosis,
treatment, aswell as inbiomedical research, has great current
medicinal significance; this is the focus of concentrated
effort across the scientific research spectrum. In particular,
organoselenium and/or organosulfur molecules show great
promise in the detection of reactive oxygen/nitrogen species
(ROS/RNS) - key factors in ageing/neurodegenerative disease
in living systems.4 The boron dipyrromethene (BODIPY)
system is a versatile class of fluorescent dye; it is commonly
used in labelling, chemosensing, light-harvesting, and solar
cell applications due to the many compelling characteristics,
including an intense absorption profile, a sharp fluorescence
emission spectrum, and high fluorescence quantum yield.
As part of our ongoing effort to study chalcogenide systems,
dithiomaleimide- and phenylselenide probes (among many
others) have been designed, synthesized and characterized.
Commonly, fluorescence is quenched by photoinduced
electron transfer (PeT) mechanism. These probes show a
“turn-on” fluorescence response upon reaction with ONOO-
(BDP-NGM) and HOCl (Mes-BOD-SePh) with significant
increase in emission intensity with fast response to ROS/RNS.
Related studies with superoxide have also been published.
Live cell imaging showed that the current probes can be used
for the selective detection of ROS and RNS in living systems.5
Time-permitting, we should also like to briefly showcase
related fluorescent probes and studies.
Speaker Biography
David G. Churchill currently working in the Molecular Logic Gate Laboratory,He is a
professor for the department of chemistry in Korea Advanced Institute of Science and
Technology
e:
dchurchill@kaist.ac.krDavid G. Churchill, Neurosurg 2017, 2:2
DOI: 10.21767/2471-9633-C1-005