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August 14-16, 2017 | Toronto, Canada
BRAIN DISORDERS AND DEMENTIA CARE
4th International Conference on
Neurosurg, an open access journal
ISSN: 2471-9633
Innovations in Novel Formulation strategies for Post Traumatic Epilepsy
Gannu Praveen Kumar
Sahasra Institute of Pharmaceutical Sciences, India
Posttraumatic epilepsy (PTE) is a major long-term
complication of traumatic brain injury (TBI). PTE usually
develops within 5 years of head injury. The risk for
developing PTE varies with TBI type. Antiepileptic drug (AED)
prophylaxis seems to be effective in controlling the early
provoked seizures. One pitfall is that AEDs tend to have a
high incidence of side effects. Many of these side effects
are due to actions on the central nervous system such as
cognitive impairment and neurobehavioral problems. These
unwanted sides effects could be augmented in patients
with TBI. An attempt was made to develop nanosystems of
carbamazepine, a nonsedative antiepileptic to prevent side
effects.
Purpose: Carbamazepine (CBZ) is a major antiepileptic drug
with clinical efficacy against post traumatic epilepsy. A novel
nanosystem for CBZ was developed to have acceptable
tolerability for human use. Such Nano systems of CBZ have
been proposed to be suitable for administration in treatment
of Posttraumatic epilepsy epilepsy.
Method: A series of seizures in 30 min was induced by
repeated trans auricular electrical stimulation in rats. In this
model of epilepsy, the anticonvulsant potency of novel Nano
system of CBZ was evaluated with that of reference standard.
Results: The rate of absorption from novel Nano systems of
carbamazepinewas 1.5 fold than fromsuspension. Averyhigh
significant improvement in half life and oral bioavailability
was observed with Nano system of carbamazepine. In both
groups, CBZ suppressed seizures after oral administration.
Potent anticonvulsant activity was obtained as early as 10
mins (Nano system was rapid) & 25 mins (suspension) after
oral administration, peak effects were observed at 20 mins
(Nano system) & 45 mins (suspension) respectively. ED50
for blockade of seizures throughout the 30-min period of
repeated electrical stimulation was 5 mg/kg. The Nano
system was tolerated by the animals with no pronounced
behavioural or motor adverse effects, the marketed
preparation (suspension) induced marked sedation and
motor impairment, indicating possibly because of erratic
absorption profile of carbamazepine as cited in the previous
literature.
Conclusion: The use of antiepileptic drugs at an early stage
in order to prevent Post traumatic epilepsy is beneficial.
This showed a good efficacy in the prevention of early post
traumatic seizures. A novel Nano system of CBZ might be
suitable for future administration for its use because CBZ
has the advantage of being almost free of respiratory or
cardiovascular adverse effects.
Keywords: Trauma, Neurological, Epilepsy, Carbamazepine,
Innovation
Speaker Biography
Gannu Praveen Kumar is currently working as Professor and Principal in Sahasra
Institute of Pharmaceutical Sciences. He is an external examiner for Post Graduation
and PhD. He has guided M. Pharm and PhD students. He published in both National
and International journals of repute. He received Gem of India award in the year 1999.
He visited London, Dubai, Spain, Singapore, Malaysia and USA as invited speaker.
e:
Gannu Praveen Kumar, Neurosurg 2017, 2:2
DOI: 10.21767/2471-9633-C1-005