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Volume 4 Nano Research & Applications
ISSN: 2471-9838
Notes:
JOINT EVENT
October 04-05, 2018 Moscow, Russia
&
2nd Edition of International Conference on
26th International Conference on Advanced Nanotechnology
Materials Technology and Manufacturing Innovations
Advanced Nanotechnology 2018
& Materials-Manufacturing 2018
October 04-05, 2018 Page 17
A D Levin
All-Russian Research Institute for Optical and Physical Measurements, Russia
A D Levin, Nano Res Appl 2018, Volume 4
DOI: 10.21767/2471-9838-C5-019
Optical nanosensor based on light scattering: Physical principles and applications for medical
diagnostics and food control
Optical sensors based on size and shape change the functionalized nanoparticles (NP) due to interaction with the
analyte are considered. NP’s are functionalized by antibodies and in the case of presence of the specific analyte
in the solution aggregation or shell formation process occurs. The change in particle size caused by these processes is
controlled using dynamic light scattering (DLS) or resonance light scattering (RLS) spectroscopy. Both optical methods
are available and non-invasive. Such techniques have several advantages in comparison with the conventional immune-
chemical analysis–they are washing-free and time-saving. For medical applications nanoparticles sizing in blood plasma
is required, for this purpose depolarized light scattering helps to distinguish light scattering of conjugates from the
scattering of plasma proteins. The model describing the kinetics of functionalized NP size increasing was developed and
applied for the optimization of nanosensor parameters (material, size, shape and concentration of NP). Experimental
results on DLS based nanosensor for the disease markers and food contaminants are presented. New DLS instrument
and data processing algorithms developed for applications with optical nanosensor gives the additional opportunities–
non-spherical NP sizing using multi-polarization DLS, estimation of NP number concentration and, subtraction of the
background NP size distribution.
Biography
Alexander Levin is Leading Research Scientist of theAll-Russian Research Institute for Optical and Physical Measurements. He received PhD in Experimen-
tal Physics in 1981, he worked in various scientific and managerial positions in the field of laser methods of diagnostic, physical optics, developing of ana-
lytical spectral instruments for atomic and molecular spectroscopy, photon correlation spectroscopy. Since 2007 he is Doctor of Engineering Science, head
of the scientific group, developing optical methods and instruments for nanoparticles characterization. Dr. Levin currently manages the projects on optical
nanosensors and development of reference materials for fluorescence. He is the author and coauthor of the 3 monographs, over 80 scientific publications
and 10 inventions. He has given many lectures at various national and international scientific conferences.