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A p r i l 1 8 - 1 9 , 2 0 1 9
P a r i s , F r a n c e
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Nano Research & Applications
ISSN: 2471-9838
Advanced Nanotechnology 2019
EuroSciCon Conference on
Advanced Nanotechnology
I
onic polysaccharides (e.g. hyaluronan (HA)) are currently used in a range of sizes, or molar masses, in an increasing number of
nanomaterials for biocompatible applications. The aim of this work is to predict the scaling law of HA, in aqueous salt solution,
by applying simple and low-cost methods of green degradation and molar mass determination. In this respect, moderately
concentrated solutions of native and different ultraviolet (UV) -degraded HA in NaCl aqueous solution were prepared. The
corresponding molar masses were obtained via one-point method of viscosity measurements. It has been observed that the
progress of molar mass production, via HA degradation, was UV-dose dependent. The graphical interpretation method of kinetic
analysis confirmed the first order degradation rate, which is an indication of a random session on the glycosidic bonds. The
viscosity data were treated via Flory-Fox's theory to get molecular parameters such as: the hydrodynamic radius (RH, η), radius
of gyration (RG, η), coil density (Ρcoin, η), critical concentration (C η*) and second virial coefficient (A2,η). It has been found that:
RH, η and RG, η represents UV-dose decreases; while, Ρcoin, η, C η* and A2,η represents UV-dose increases. The results were
explained according to the influence of size and excluded-volume.
tahanialfazani
19@gmail.comNanoscaled polysaccharides in solution: scaling
laws of hyaluronan
Tahani Alfazani, Fathi Shaker Mohamed Elashhab and Lobna Sheha
University of Benghazi, Libya
Nano Res Appl 2019, Volume:5
DOI: 10.21767/2471-9838-C2-034