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Nano Research & Applications
ISSN: 2471-9838
Advanced Nanotechnology 2019
EuroSciCon Conference on
Advanced Nanotechnology
Introduction:
This research was aimed to design a method to determine verapamil HCl in dosage forms by using CdTe/CdS/ZnS
core-shell QDs as a fluorescent probe.
Methods:
CdTe/CdS/ZnS quantum dots were prepared by one pot method and analyzed. An analytical technique based on
fluorescence quenching of QDs was developed to quantify verapamil in commercially available preparations. Various reaction
parameters were optimized and the method developed was validated. One way ANOVA and Post Hoc tests at 5% significance
level, were performed to justify the significance of variation in observations.
Results:
Linear range of the verapamil concentration was 0.25-5 µg/mL while limit of detection was 0.05µg/mL. Recovery and
relative standard deviations were NMT±10% of the actual amount and <5.9%, respectively. Foreign materials, common metal
ions and pharmaceutical excipients of dosage forms, had little interference. Verapamil content in the tablets and injections was
NMT±10% of the stated amount and it conformed to the specifications of both the British Pharmacopoeia and the United States
Pharmacopoeia. In case of statistical analysis, p-value was <0.05 in almost all levels of all parameters until the optimized level
of system.
Conclusions:
It can be concluded from the results that the method designed is simple, reliable, cost effective, selective, rapid and
sensitive enough to be used for quantitative measurement of the verapamil HCl in dosage forms for quality control purposes.
drsohail87@hotmail.com msohail@njmu.edu.cnDetermination of verapamil HCl in
pharmaceutical preparations by a fluorescent
nano probe based on CdTe/CdS/ZnS quantum dots
Sohail M and Qin Hu
School of Pharmacy-Nanjing Medical University, PR China
Nano Res Appl 2019, Volume:5
DOI: 10.21767/2471-9838-C2-034