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A p r i l 1 8 - 1 9 , 2 0 1 9

P a r i s , F r a n c e

Page 50

Nano Research & Applications

ISSN: 2471-9838

Advanced Nanotechnology 2019

EuroSciCon Conference on

Advanced Nanotechnology

Introduction:

This research was aimed to design a method to determine verapamil HCl in dosage forms by using CdTe/CdS/ZnS

core-shell QDs as a fluorescent probe.

Methods:

CdTe/CdS/ZnS quantum dots were prepared by one pot method and analyzed. An analytical technique based on

fluorescence quenching of QDs was developed to quantify verapamil in commercially available preparations. Various reaction

parameters were optimized and the method developed was validated. One way ANOVA and Post Hoc tests at 5% significance

level, were performed to justify the significance of variation in observations.

Results:

Linear range of the verapamil concentration was 0.25-5 µg/mL while limit of detection was 0.05µg/mL. Recovery and

relative standard deviations were NMT±10% of the actual amount and <5.9%, respectively. Foreign materials, common metal

ions and pharmaceutical excipients of dosage forms, had little interference. Verapamil content in the tablets and injections was

NMT±10% of the stated amount and it conformed to the specifications of both the British Pharmacopoeia and the United States

Pharmacopoeia. In case of statistical analysis, p-value was <0.05 in almost all levels of all parameters until the optimized level

of system.

Conclusions:

It can be concluded from the results that the method designed is simple, reliable, cost effective, selective, rapid and

sensitive enough to be used for quantitative measurement of the verapamil HCl in dosage forms for quality control purposes.

drsohail87@hotmail.com msohail@njmu.edu.cn

Determination of verapamil HCl in

pharmaceutical preparations by a fluorescent

nano probe based on CdTe/CdS/ZnS quantum dots

Sohail M and Qin Hu

School of Pharmacy-Nanjing Medical University, PR China

Nano Res Appl 2019, Volume:5

DOI: 10.21767/2471-9838-C2-034