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Nano Research & Applications
ISSN: 2471-9838
Advanced Nanotechnology 2019
EuroSciCon Conference on
Advanced Nanotechnology
E
ngineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging
and therapy is an important nanomedical challenge. To overcome this challenge we designed a nanostructure with NIR
plasmonic signatures composed of a 50 nm Au core surrounded a SiO2 inner-shell doped with contrast agents and an outer Au
shell. The plasmon resonance of this nanostructure, known as a nanomatryoshka (NM), can be tuned to the desired wavelength
by varying the thickness of the layers. The encapsulated contrast agents used in this study are: Fe (III)-DOTA, Gd(III)-DOTA,
and fluorescent dyes. The Fe (III)-NM based contrast agents are found to have relaxivities two times greater than the widely
used Gd(III)-DOTA, providing a practical alternative for T1 MRI contrast agent that eliminates Gd(III) patient exposure entirely.
Additionally, the internalization of fluorescent dyes and MRI contrast imaging agents within the NM substantially reduces the
toxicity while maintaining a free nanoparticles surface for further bio-functionalization.
Oara.Neumann@rice.eduMRI and fluorescent active plasmonic
nanomatryoshka
Oara Neumann
Rice University, USA
Nano Res Appl 2019, Volume:5
DOI: 10.21767/2471-9838-C2-034